Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain
In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an “inside-out” organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of t...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2024
|
| In: |
Cerebral cortex
Year: 2024, Jahrgang: 34, Heft: 2, Pages: 1-20 |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhae023 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/cercor/bhae023 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/cercor/article/34/2/bhae023/7611065 
|
| Verfasserangaben: | Nieves Mingo-Moreno, Pavel Truschow, Jochen F. Staiger, Robin J. Wagener |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1914590392 | ||
| 003 | DE-627 | ||
| 005 | 20250716222344.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250114s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cercor/bhae023 |2 doi | |
| 035 | |a (DE-627)1914590392 | ||
| 035 | |a (DE-599)KXP1914590392 | ||
| 035 | |a (OCoLC)1528016392 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Moreno, Nieves Mingo |d 1986- |e VerfasserIn |0 (DE-588)1204643601 |0 (DE-627)1690022469 |4 aut | |
| 245 | 1 | 0 | |a Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain |c Nieves Mingo-Moreno, Pavel Truschow, Jochen F. Staiger, Robin J. Wagener |
| 264 | 1 | |c February 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.01.2025 | ||
| 520 | |a In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an “inside-out” organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of the reelin gene. Using RNA in situ hybridization we could demonstrate that the Reelin-deficient mouse cortex (male and female) displays an increasing lamination defect along the rostro-caudal axis that is characterized by strong cellular intermingling, but roughly reproduces the “inside-out” pattern in rostral cortex, while caudal cortex shows a relative inversion of neuronal positioning (“outside-in”). We found that in development of the reeler cortex, preplate-splitting is also defective with an increasing severity along the rostro-caudal axis. This leads to a misplacement of subplate neurons that are crucial for a switch in migration mode within the cortical plate. Using Flash Tag labeling and nucleoside analog pulse-chasing, we found an according migration defect within the cortical plate, again with a progressive severity along the rostro-caudal axis. Thus, loss of one key player in neocortical development leads to highly area-specific (caudally pronounced) developmental deficiencies that result in multiple roughly opposite rostral versus caudal adult neocortical phenotypes. | ||
| 700 | 1 | |a Truschow, Pavel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Staiger, Jochen F. |d 1964- |e VerfasserIn |0 (DE-588)1111568596 |0 (DE-627)865637628 |0 (DE-576)476173906 |4 aut | |
| 700 | 1 | |a Wagener, Jan Robin |d 1981- |e VerfasserIn |0 (DE-588)1046902970 |0 (DE-627)777296500 |0 (DE-576)398861803 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cerebral cortex |d Oxford : Oxford Univ. Press, 1991 |g 34(2024), 2 vom: Feb., Artikel-ID bhae023, Seite 1-20 |h Online-Ressource |w (DE-627)300896948 |w (DE-600)1483485-6 |w (DE-576)088704572 |x 1460-2199 |7 nnas |a Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain |
| 773 | 1 | 8 | |g volume:34 |g year:2024 |g number:2 |g month:02 |g elocationid:bhae023 |g pages:1-20 |g extent:20 |a Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain |
| 856 | 4 | 0 | |u https://doi.org/10.1093/cercor/bhae023 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/cercor/article/34/2/bhae023/7611065 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250114 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1046902970 |a Wagener, Jan Robin |m 1046902970:Wagener, Jan Robin |d 910000 |d 911100 |e 910000PW1046902970 |e 911100PW1046902970 |k 0/910000/ |k 1/910000/911100/ |p 4 |y j | ||
| 999 | |a KXP-PPN1914590392 |e 4651330843 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 14.01.2025"],"id":{"eki":["1914590392"],"doi":["10.1093/cercor/bhae023"]},"title":[{"title":"Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain","title_sort":"Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain"}],"recId":"1914590392","language":["eng"],"origin":[{"dateIssuedDisp":"February 2024","dateIssuedKey":"2024"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"disp":"Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brainCerebral cortex","note":["Gesehen am 05.01.2017"],"title":[{"title_sort":"Cerebral cortex","title":"Cerebral cortex"}],"id":{"issn":["1460-2199"],"eki":["300896948"],"zdb":["1483485-6"]},"part":{"pages":"1-20","year":"2024","extent":"20","issue":"2","volume":"34","text":"34(2024), 2 vom: Feb., Artikel-ID bhae023, Seite 1-20"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"dateIssuedKey":"1991","publisherPlace":"Oxford","dateIssuedDisp":"1991-","publisher":"Oxford Univ. Press"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1991 -"],"recId":"300896948"}],"name":{"displayForm":["Nieves Mingo-Moreno, Pavel Truschow, Jochen F. Staiger, Robin J. Wagener"]},"person":[{"role":"aut","display":"Moreno, Nieves Mingo","given":"Nieves Mingo","family":"Moreno","roleDisplay":"VerfasserIn"},{"given":"Pavel","display":"Truschow, Pavel","role":"aut","family":"Truschow","roleDisplay":"VerfasserIn"},{"family":"Staiger","roleDisplay":"VerfasserIn","given":"Jochen F.","role":"aut","display":"Staiger, Jochen F."},{"roleDisplay":"VerfasserIn","family":"Wagener","given":"Jan Robin","display":"Wagener, Jan Robin","role":"aut"}],"physDesc":[{"extent":"20 S.","noteIll":"Illustrationen"}]} | ||
| SRT | |a MORENONIEVCAUDALLYPR2024 | ||