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Improvement of breast cancer detection using dual-layer spectral CT

This study aimed to investigate the diagnostic performance of breast mass detection on monoenergetic image data at 40 keV (MonoE40) and on iodine maps (IM) compared with conventional image data (CI). In this prospective single-center case-control study, 50 breast cancer patients were examined using...

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Main Authors: Hasse, Felix (Author) , Giannakis, Athanasios (Author) , Wehrse, Eckhard (Author) , Stiller, Wolfram (Author) , Wallwiener, Markus (Author) , Kauczor, Hans-Ulrich (Author) , Weber, Tim (Author) , Heil, Jörg (Author) , Mokry, Theresa (Author)
Format: Article (Journal)
Language:English
Published: 19 July 2024
In: Diagnostics
Year: 2024, Volume: 14, Issue: 14, Pages: 1-11
ISSN:2075-4418
DOI:10.3390/diagnostics14141560
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics14141560
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/14/14/1560
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Author Notes:Felix Christian Hasse, Athanasios Giannakis, Eckhard Wehrse, Wolfram Stiller, Markus Wallwiener, Hans-Ulrich Kauczor, Tim F. Weber, Jörg Heil and Theresa Mokry
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Summary:This study aimed to investigate the diagnostic performance of breast mass detection on monoenergetic image data at 40 keV (MonoE40) and on iodine maps (IM) compared with conventional image data (CI). In this prospective single-center case-control study, 50 breast cancer patients were examined using contrast-enhanced dual-layer spectral CT. For qualitative and quantitative comparison of MonoE40 and IM with CI image data, four blinded, independent readers assessed 300 randomized single slices (two slices for each imaging type per case) with or without cancerous lesions for the presence of a breast mass. Detection sensitivity and specificity were calculated and readers rated their subjective diagnostic certainty. For statistical analysis of sensitivity and specificity, a paired t-test and ANOVA were used (significance level p = 0.05). A total of 50 female patients (median age 51 years, range 28-83 years) participated. IM had the highest overall scores in sensitivity and specificity for breast cancer detection, with 0.97 ± 0.06 and 0.95 ± 0.07, respectively, compared with 0.90 ± 0.04 and 0.92 ± 0.06 in CI. MonoE40 yielded a sensitivity of 0.96 ± 0.02 and specificity of 0.94 ± 0.08. All differences in sensitivity and specificity between MonoE or IM and CI were statistically significant (p < 0.001). The superiority of IM sensitivity and specificity was most pronounced in patients with dense breasts. Spectral CT improved the detection of breast cancer with higher sensitivity and specificity compared to conventional image data in our study.
Item Description:Gesehen am 15.01.2025
Physical Description:Online Resource
ISSN:2075-4418
DOI:10.3390/diagnostics14141560

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