Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

Certain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and preclinical data indicate potential benefit in selected paediatric brain tumour entities. However, limited single-agent efficacy necessitates combination treatment approac...

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Main Authors:	Seiboldt, Till (Author) , Zeiser, Constantia (Author) , Nguyen, Duy (Author) , Çelikyürekli, Simay (Author) , Herter, Sonja (Author) , Najafi, Sara (Author) , Stroh-Dege, Alexandra (Author) , Meulenbroeks, Chris (Author) , Mack, Norman (Author) , Salem-Altintas, Rabia (Author) , Westermann, Frank (Author) , Schlesner, Matthias (Author) , Milde, Till (Author) , Kool, Marcel (Author) , Holland-Letz, Tim (Author) , Vogler, Meike (Author) , Peterziel, Heike (Author) , Witt, Olaf (Author) , Oehme, Ina (Author)
Format:	Article (Journal)
Language:	English
Published:	28 June 2024
In:	British journal of cancer Year: 2024, Volume: 131, Issue: 4, Pages: 763-777
ISSN:	1532-1827
DOI:	10.1038/s41416-024-02740-5
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41416-024-02740-5 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-024-02740-5
Author Notes:	Till Seiboldt, Constantia Zeiser, Duy Nguyen, Simay Celikyürekli, Sonja Herter, Sara Najafi, Alexandra Stroh-Dege, Chris Meulenbroeks, Norman Mack, Rabia Salem-Altintas, Frank Westermann, Matthias Schlesner, Till Milde, Marcel Kool, Tim Holland-Letz, Meike Vogler, Heike Peterziel, Olaf Witt and Ina Oehme