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Genetics of type III hyperlipoproteinemia

One hundred forty-seven relatives of 43 patients with “classical” type III hyperlipoproteinemia (HLP) having the apolipoprotein (apo) E2/2 phenotype were studied to determine the occurrence of hyperlipidemia and the presence of further possible genes for lipoprotein disorders in these families. In 1...

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Bibliographic Details
Main Authors: Feussner, Giso (Author) , Piesch, Susanne (Author) , Dobmeyer, Jürgen (Author) , Fischer, Christine (Author)
Format: Article (Journal)
Language:English
Published: 1997
In: Genetic epidemiology
Year: 1997, Volume: 14, Issue: 3, Pages: 283-297
ISSN:1098-2272
DOI:10.1002/(SICI)1098-2272(1997)14:3<283::AID-GEPI6>3.0.CO;2-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1098-2272(1997)14:3<283::AID-GEPI6>3.0.CO;2-6
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2272%281997%2914%3A3%3C283%3A%3AAID-GEPI6%3E3.0.CO%3B2-6
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Author Notes:Giso Feussner, Susanne Piesch, Jürgen Dobmeyer, Christine Fischer
Description
Summary:One hundred forty-seven relatives of 43 patients with “classical” type III hyperlipoproteinemia (HLP) having the apolipoprotein (apo) E2/2 phenotype were studied to determine the occurrence of hyperlipidemia and the presence of further possible genes for lipoprotein disorders in these families. In 12 pedigrees primary dyslipidemia was prevalent among patients and respective blood-relatives. In these kindreds the coexistent presence of genes for familial combined hyperlipidemia (n = 6), familial hypertriglyceridemia (n = 5), and familial hypercholesterolemia (n = 1), respectively, was supposed. Our results, therefore, confirm and extend previous data on the multifactorial genesis of the diseases. Besides homozygosity for a receptor binding-defective isoform of apo E (apo E2), additional genes for familial lipoprotein disorders might operate in the pathogenesis of type III HLP. This is the largest family study performed so far in this primary lipoprotein disorder. Genet. Epidemiol. 14:283-297,1997. © 1997 Wiley-Liss, Inc.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 6. Dezember 1998
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Physical Description:Online Resource
ISSN:1098-2272
DOI:10.1002/(SICI)1098-2272(1997)14:3<283::AID-GEPI6>3.0.CO;2-6

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