Cover Image

Potential correlation between anti-laminin 332 autoantibodies and malignant tumours in anti-BP180-type mucous membrane pemphigoid

Dear Editor, Several studies have indicated a correlation between the presence of malignant tumours and anti-laminin 332 (LM332)-type mucous membrane pemphigoid (MMP),1,2 in contrast to the absence of such a correlation in patients with anti-BP180-type MMP (BP180-MMP).3 It has been observed that ant...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Xiaoguang (Author) , Pas, Hendri H (Author) , Qian, Hua (Author) , Rashid, Hanan (Author) , Horvath, Barbara (Author) , Yilmaz, Osman K. (Author) , Beek, Nina van (Author) , Schmidt, Enno (Author) , Zillikens, Detlef (Author) , Ishii, Norito (Author) , Tsuruta, Daisuke (Author) , Hashimoto, Takashi (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Clinical and experimental dermatology
Year: 2024, Volume: 49, Issue: 9, Pages: 1075-1076
ISSN:1365-2230
DOI:10.1093/ced/llae124
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ced/llae124
Get full text
Author Notes:Xiaoguang Li, Hendri H Pas, Hua Qian, Hanan Rashid, Barbara Horvath, Kaan Yilmaz, Nina van Beek, Enno Schmidt, Detlef Zillikens, Norito Ishii, Daisuke Tsuruta, Takashi Hashimoto
Description
Summary:Dear Editor, Several studies have indicated a correlation between the presence of malignant tumours and anti-laminin 332 (LM332)-type mucous membrane pemphigoid (MMP),1,2 in contrast to the absence of such a correlation in patients with anti-BP180-type MMP (BP180-MMP).3 It has been observed that anti-LM332 autoantibodies may also be present in patients with BP180-MMP.3 In the present study, we assessed the relationship between anti-LM332 autoantibodies and the incidence of malignant tumours in patients with BP180-MMP.We recruited 520 patients with BP180-MMP, including 331 patients from Japan, 19 from China, 108 from the Netherlands and 62 from Germany. Essential criteria for BP180-MMP diagnosis include reactivity with the epidermal side in indirect immunofluorescence using 1 M NaCl split skin, positivity for anti-BP180 autoantibodies in immunoblotting of epidermal extract, and/or immunoblotting and/or enzyme-linked immunosorbent assay of recombinant proteins of BP180 NC16a and/or C-terminal domains. The detection of anti-LM332 autoantibodies was conducted utilizing various methods among multiple cohorts: by immunoblotting of purified LM332 or its recombinant protein in the Japanese and Chinese cohorts;1,3 by keratinocyte footprint assay in the Dutch cohort;4 by indirect immunofluorescence (Biochip® Mosaic; EUROIMMUN, Lübeck, Germany)2,4 and immunoblotting of keratinocyte-derived LM332 in the German cohort.
Item Description:Online veröffentlicht: 18. April 2024
Gesehen am 22.01.2025
Physical Description:Online Resource
ISSN:1365-2230
DOI:10.1093/ced/llae124

Similar Items