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Potential correlation between anti-laminin 332 autoantibodies and malignant tumours in anti-BP180-type mucous membrane pemphigoid

Dear Editor, Several studies have indicated a correlation between the presence of malignant tumours and anti-laminin 332 (LM332)-type mucous membrane pemphigoid (MMP),1,2 in contrast to the absence of such a correlation in patients with anti-BP180-type MMP (BP180-MMP).3 It has been observed that ant...

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Hauptverfasser: Li, Xiaoguang (VerfasserIn) , Pas, Hendri H (VerfasserIn) , Qian, Hua (VerfasserIn) , Rashid, Hanan (VerfasserIn) , Horvath, Barbara (VerfasserIn) , Yilmaz, Osman K. (VerfasserIn) , Beek, Nina van (VerfasserIn) , Schmidt, Enno (VerfasserIn) , Zillikens, Detlef (VerfasserIn) , Ishii, Norito (VerfasserIn) , Tsuruta, Daisuke (VerfasserIn) , Hashimoto, Takashi (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 2024
In: Clinical and experimental dermatology
Year: 2024, Jahrgang: 49, Heft: 9, Pages: 1075-1076
ISSN:1365-2230
DOI:10.1093/ced/llae124
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ced/llae124
Volltext
Verfasserangaben:Xiaoguang Li, Hendri H Pas, Hua Qian, Hanan Rashid, Barbara Horvath, Kaan Yilmaz, Nina van Beek, Enno Schmidt, Detlef Zillikens, Norito Ishii, Daisuke Tsuruta, Takashi Hashimoto
Beschreibung
Zusammenfassung:Dear Editor, Several studies have indicated a correlation between the presence of malignant tumours and anti-laminin 332 (LM332)-type mucous membrane pemphigoid (MMP),1,2 in contrast to the absence of such a correlation in patients with anti-BP180-type MMP (BP180-MMP).3 It has been observed that anti-LM332 autoantibodies may also be present in patients with BP180-MMP.3 In the present study, we assessed the relationship between anti-LM332 autoantibodies and the incidence of malignant tumours in patients with BP180-MMP.We recruited 520 patients with BP180-MMP, including 331 patients from Japan, 19 from China, 108 from the Netherlands and 62 from Germany. Essential criteria for BP180-MMP diagnosis include reactivity with the epidermal side in indirect immunofluorescence using 1 M NaCl split skin, positivity for anti-BP180 autoantibodies in immunoblotting of epidermal extract, and/or immunoblotting and/or enzyme-linked immunosorbent assay of recombinant proteins of BP180 NC16a and/or C-terminal domains. The detection of anti-LM332 autoantibodies was conducted utilizing various methods among multiple cohorts: by immunoblotting of purified LM332 or its recombinant protein in the Japanese and Chinese cohorts;1,3 by keratinocyte footprint assay in the Dutch cohort;4 by indirect immunofluorescence (Biochip® Mosaic; EUROIMMUN, Lübeck, Germany)2,4 and immunoblotting of keratinocyte-derived LM332 in the German cohort.
Beschreibung:Online veröffentlicht: 18. April 2024
Gesehen am 22.01.2025
Beschreibung:Online Resource
ISSN:1365-2230
DOI:10.1093/ced/llae124

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