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Morphological signatures of neurogenesis and neuronal migration in hypothalamic vasopressinergic magnocellular nuclei of the adult rat

The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction agains...

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Main Authors: Zhang, Limei (Author) , Zetter, Mario A. (Author) , Hernández, Vito S. (Author) , Hernández-Pérez, Oscar R. (Author) , Jáuregui-Huerta, Fernando (Author) , Krabichler, Quirin (Author) , Grinevich, Valéry (Author)
Format: Article (Journal)
Language:English
Published: 26 June 2024
In: International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 13, Pages: 1-25
ISSN:1422-0067
DOI:10.3390/ijms25136988
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25136988
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/25/13/6988
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Author Notes:Limei Zhang, Mario A. Zetter, Vito S. Hernández, Oscar R. Hernández-Pérez, Fernando Jáuregui-Huerta, Quirin Krabichler and Valery Grinevich
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Summary:The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial fibrillar acidic protein (GFAP), cell division marker (Ki67), migrating neuroblast markers (doublecortin, DCX), microglial marker (Ionized calcium binding adaptor molecule 1, Iba1), and 5′-bromo-2′-deoxyuridine (BrdU), we report morphological evidence that low-rate neurogenesis and migration occur in adult AVPMNS in the rat hypothalamus. Tangential AVP/GFAP migration routes and AVP/DCX neuronal chains as well as ascending AVP axonal scaffolds were observed. Chronic water deprivation significantly increased the BrdU+ nuclei within both the supraaoptic (SON) and paraventricular (PVN) nuclei. These findings raise new questions about AVPMNS’s potential hormonal role for brain physiological adaptation across the lifespan, with possible involvement in coping with homeostatic adversities.
Item Description:Gesehen am 23.01.2025
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms25136988

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