Characteristics of H3K27M-mutant diffuse gliomas with a non-midline location

Diffuse midline gliomas (DMG) with H3K27 alterations (H3K27M-DMG) are a highly aggressive form of brain cancer. In rare cases, H3K27 mutations have been observed in diffuse non-midline gliomas (DNMG). It is currently unclear how these tumors should be classified. Herein, we analyze the characteristi...

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Main Authors: Guidara, Souhir (Author) , Seyve, Antoine (Author) , Poncet, Delphine (Author) , Leonce, Camille (Author) , Bringuier, Pierre-Paul (Author) , McLeer, Anne (Author) , Sturm, Dominik (Author) , Cartalat, Stéphanie (Author) , Picart, Thiebaud (Author) , Ferrari, Anthony (Author) , Hench, Jürgen (Author) , Frank, Stephan (Author) , Meyronet, David (Author) , Ducray, François (Author) , Barritault, Marc (Author)
Format: Article (Journal)
Language:English
Published: 27 June 2024
In: Journal of neuro-oncology
Year: 2024, Volume: 169, Issue: 2, Pages: 391-398
ISSN:1573-7373
DOI:10.1007/s11060-024-04733-z
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11060-024-04733-z
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Author Notes:Souhir Guidara, Antoine Seyve, Delphine Poncet, Camille Leonce, Pierre-Paul Bringuier, Anne McLeer, Dominik Sturm, Stéphanie Cartalat, Thiebaud Picart, Anthony Ferrari, Jürgen Hench, Stephan Frank, David Meyronet, François Ducray, Marc Barritault
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Summary:Diffuse midline gliomas (DMG) with H3K27 alterations (H3K27M-DMG) are a highly aggressive form of brain cancer. In rare cases, H3K27 mutations have been observed in diffuse non-midline gliomas (DNMG). It is currently unclear how these tumors should be classified. Herein, we analyze the characteristics of DNMG with H3K27M mutations.
Item Description:Gesehen am 24.01.2025
Physical Description:Online Resource
ISSN:1573-7373
DOI:10.1007/s11060-024-04733-z