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Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy?: Medical imaging : radiation oncology

Introduction In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in...

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Main Authors: Steinberg, Hannah Luisa (Author) , Ting, Saskia C (Author) , Zensen, Sebastian (Author) , Ludwig, Johannes Maximilian (Author) , Li, Yan (Author) , Richly, Heike (Author) , Grüneisen, Johannes (Author) , Siveke, Jens T (Author) , Theysohn, Jens M (Author) , Schaarschmidt, Benedikt M (Author)
Format: Article (Journal)
Language:English
Published: October 2024
In: Journal of medical imaging and radiation oncology
Year: 2024, Volume: 68, Issue: 7, Pages: 862-869
ISSN:1754-9485
DOI:10.1111/1754-9485.13783
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/1754-9485.13783
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/1754-9485.13783
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Author Notes:Hannah L Steinberg-Vorhoff, Saskia C Ting, Sebastian Zensen, Johannes M Ludwig, Yan Li, Heike Richly, Johannes Grüneisen, Jens T Siveke, Jens M Theysohn and Benedikt M Schaarschmidt
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Summary:Introduction In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC. Methods A retrospective analysis with 60 UM patients (29 females, mean age: 61.6 ± 12.1 years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan-Meier curves and the log-rank test. Results In 73.3% (44/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13/60) a predominant spindle cell pattern, and in 5% (3/60) other patterns were found. No significant differences between patients with an epithelioid (mOS: 14.2 months, 95% CI: 8.8-19.6) and a spindle cell pattern (mOS: 14.4 months, 95% CI: 4.3-24.5) were detected by the log-rank test, χ2(2) = 0.22, P = 0.881. Conclusion Histomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC.
Item Description:Erstmals veröffentlicht: 24. September 2024
Gesehen am 27.01.2025
Physical Description:Online Resource
ISSN:1754-9485
DOI:10.1111/1754-9485.13783

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