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Alcohol-Associated liver disease outcomes: critical mechanisms of liver injury progression

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and dis...

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Main Authors: Osna, Natalia (Author) , Tikhanovich, Irina (Author) , Ortega-Ribera, Martí (Author) , Mueller, Sebastian (Author) , Zheng, Chaowen (Author) , Müller, Johannes (Author) , Li, Siyuan (Author) , Sakane, Sadatsugu (Author) , Weber, Raquel Carvalho Gontijo (Author) , Kim, Hyun Young (Author) , Lee, Wonseok (Author) , Ganguly, Souradipta (Author) , Kimura, Yusuke (Author) , Liu, Xiao (Author) , Dhar, Debanjan (Author) , Diggle, Karin (Author) , Brenner, David A. (Author) , Kisseleva, Tatiana (Author) , Attal, Neha (Author) , McKillop, Iain H. (Author) , Chokshi, Shilpa (Author) , Mahato, Ram (Author) , Rasineni, Karuna (Author) , Szabo, Gyongyi (Author) , Kharbanda, Kusum K. (Author)
Format: Article (Journal)
Language:English
Published: 27 March 2024
In: Biomolecules
Year: 2024, Volume: 14, Issue: 4, Pages: 1-25
ISSN:2218-273X
DOI:10.3390/biom14040404
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biom14040404
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2218-273X/14/4/404
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Author Notes:Natalia A. Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim, Wonseok Lee, Souradipta Ganguly, Yusuke Kimura, Xiao Liu, Debanjan Dhar, Karin Diggle, David A. Brenner, Tatiana Kisseleva, Neha Attal, Iain H. McKillop, Shilpa Chokshi, Ram Mahato, Karuna Rasineni, Gyongyi Szabo and Kusum K. Kharbanda
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Summary:Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.
Item Description:Gesehen am 28.01.2025
Physical Description:Online Resource
ISSN:2218-273X
DOI:10.3390/biom14040404

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