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Pharmacological treatment of depression in patients with brain tumors

Patients with brain tumors suffer from intense psychosocial distress. Although the prevalence of depressive symptoms in patients with brain tumors is high, the pharmacological antidepressant treatment of those patients is not well defined and results from clinical trials are largely missing. In this...

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Bibliographic Details
Main Authors: Knabbe, Johannes (Author) , Kowalski, Thomas (Author) , Seliger, Corinna (Author)
Format: Article (Journal)
Language:English
Published: 1 November 2024
In: International journal of cancer
Year: 2024, Volume: 155, Issue: 9, Pages: 1533-1543
ISSN:1097-0215
DOI:10.1002/ijc.35058
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.35058
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.35058
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Author Notes:Johannes Knabbe, Thomas Kowalski, Corinna Seliger
Description
Summary:Patients with brain tumors suffer from intense psychosocial distress. Although the prevalence of depressive symptoms in patients with brain tumors is high, the pharmacological antidepressant treatment of those patients is not well defined and results from clinical trials are largely missing. In this review, we describe the current standard of evidence and clinical guidelines for the pharmacological treatment of depression in brain tumor patients. We present specific side effects and interactions that should guide treatment decisions. Furthermore, we provide evidence for the diagnosis, screening and risk factors for depression in brain tumor patients and we elaborate on potential antineoplastic effects of antidepressant drugs and ongoing clinical trials. Antidepressant drugs should not be withheld from patients with brain tumors. Future clinical trials should explore the effectiveness and side effects of antidepressants in this specific patient population.
Item Description:Veröffentlicht: 28 June 2024
Gesehen am 29.01.2025
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.35058

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