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A fatty acid switch drives ferroptosis in EMT

Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to elimi...

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Bibliographic Details
Main Authors: Winkelkotte, Alina M. (Author) , Schulze, Almut (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Nature cell biology
Year: 2024, Volume: 26, Issue: 9, Pages: 1375-1376
ISSN:1476-4679
DOI:10.1038/s41556-024-01483-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41556-024-01483-y
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41556-024-01483-y
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Author Notes:Alina M. Winkelkotte & Almut Schulze
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Summary:Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to eliminate aggressive mesenchymal cancer cells.
Item Description:Online veröffentlicht am 13. August 2024
Gesehen am 03.02.2025
Physical Description:Online Resource
ISSN:1476-4679
DOI:10.1038/s41556-024-01483-y

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