A fatty acid switch drives ferroptosis in EMT
Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to elimi...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2024
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| In: |
Nature cell biology
Year: 2024, Jahrgang: 26, Heft: 9, Pages: 1375-1376 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/s41556-024-01483-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41556-024-01483-y Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41556-024-01483-y 
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| Verfasserangaben: | Alina M. Winkelkotte & Almut Schulze |
| Zusammenfassung: | Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to eliminate aggressive mesenchymal cancer cells. |
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| Beschreibung: | Online veröffentlicht am 13. August 2024 Gesehen am 03.02.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/s41556-024-01483-y |