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Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia

Relapsed and refractory acute myeloid leukemia (AML) carries a dismal prognosis. CAR T cells have shown limited efficacy in AML, partially due to dysfunctional autologous T cells and the extended time for generation of patient specific CAR T cells. Allogeneic NK cell therapy is a promising alternati...

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Hauptverfasser: Sedloev, David (VerfasserIn) , Chen, Qian (VerfasserIn) , Unglaub, Julia Marie (VerfasserIn) , Schanda, Nicola (VerfasserIn) , Yao, Hao (VerfasserIn) , Besiridou, Eleni (VerfasserIn) , Neuber, Brigitte (VerfasserIn) , Schmitt, Anita (VerfasserIn) , Raffel, Simon (VerfasserIn) , Liu, Yi (VerfasserIn) , Janssen, Maike (VerfasserIn) , Müller-Tidow, Carsten (VerfasserIn) , Schmitt, Michael (VerfasserIn) , Sauer, Tim (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 September 2024
In: Journal of hematology & oncology
Year: 2024, Jahrgang: 17, Pages: 1-22
ISSN:1756-8722
DOI:10.1186/s13045-024-01604-y
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13045-024-01604-y
Verlag, kostenfrei, Volltext: https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01604-y
Volltext
Verfasserangaben:David Sedloev, Qian Chen, Julia M. Unglaub, Nicola Schanda, Yao Hao, Eleni Besiridou, Brigitte Neuber, Anita Schmitt, Simon Raffel, Yi Liu, Maike Janssen, Carsten Müller-Tidow, Michael Schmitt and Tim Sauer
Beschreibung
Zusammenfassung:Relapsed and refractory acute myeloid leukemia (AML) carries a dismal prognosis. CAR T cells have shown limited efficacy in AML, partially due to dysfunctional autologous T cells and the extended time for generation of patient specific CAR T cells. Allogeneic NK cell therapy is a promising alternative, but strategies to enhance efficacy and persistence may be necessary. Proteasome inhibitors (PI) induce changes in the surface proteome which may render malignant cells more vulnerable to NK mediated cytotoxicity. Here, we investigated the potential benefit of combining PIs with CAR-expressing allogeneic NK cells against AML.
Beschreibung:Gesehen am 10.02.2025
Beschreibung:Online Resource
ISSN:1756-8722
DOI:10.1186/s13045-024-01604-y

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