The block of the expressed L-type calcium channel is modulated by the β 3 subunit
The α 1C subunit of the L-type calcium channel was stable, expressed alone or in combination with the β 3 subunit in Chinese hamster ovary cells. The β 3 subunit enhanced significantly the inactivation of barium currents indicating that both subunits interacted with each other. The β 3 subunit decre...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 09, 1995
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| In: |
FEBS letters
Year: 1995, Volume: 373, Issue: 2, Pages: 103-107 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/0014-5793(95)01013-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0014-5793(95)01013-5 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2895%2901013-5 
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| Author Notes: | L. Lacinová, A. Ludwig, E. Bosse, V. Flockerzi, F. Hofmann |
| Summary: | The α 1C subunit of the L-type calcium channel was stable, expressed alone or in combination with the β 3 subunit in Chinese hamster ovary cells. The β 3 subunit enhanced significantly the inactivation of barium currents indicating that both subunits interacted with each other. The β 3 subunit decreased signinicantly the half-maximal inhibitory concentration of the calcium channel blockers (−)-gallopamil and verapamil, but did not affect significantly the block caused by isradipine and mibefradil at the holding potentials of −80 mV and −40 mV. These results suggest that the β 3 subunit affects distinctly the interaction of the expressed α 1c subunit with different classes of organic calcium channel blockers. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 9. März 2000 Im Titel ist "3" tiefgestellt Gesehen am 13.02.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/0014-5793(95)01013-5 |