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Cardiovascular magnetic resonance reference ranges from the Healthy Hearts Consortium

Background - The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care. - Objectives - This paper provides age-, sex-, and ethnicity-specific CMR reference ranges for atrial and ventricular metrics from t...

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Main Authors: Raisi-Estabragh, Zahra (Author) , Szabo, Liliana (Author) , McCracken, Celeste (Author) , Bülow, Robin (Author) , Aquaro, Giovanni Donato (Author) , André, Florian (Author) , Le, Thu-Thao (Author) , Suchá, Dominika (Author) , Condurache, Dorina-Gabriela (Author) , Salih, Ahmed M. (Author) , Chadalavada, Sucharitha (Author) , Aung, Nay (Author) , Lee, Aaron Mark (Author) , Harvey, Nicholas C. (Author) , Leiner, Tim (Author) , Chin, Calvin W. L. (Author) , Friedrich, Matthias (Author) , Barison, Andrea (Author) , Dörr, Marcus (Author) , Petersen, Steffen E. (Author)
Format: Article (Journal)
Language:English
Published: July 2024
In: JACC Cardiovascular imaging
Year: 2024, Volume: 17, Issue: 7, Pages: 746-762
ISSN:1876-7591
DOI:10.1016/j.jcmg.2024.01.009
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jcmg.2024.01.009
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1936878X24000615
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Author Notes:Zahra Raisi-Estabragh, Liliana Szabo, Celeste McCracken, Robin Bülow, Giovanni Donato Aquaro, Florian Andre, Thu-Thao Le, Dominika Suchá, Dorina-Gabriela Condurache, Ahmed M. Salih, Sucharitha Chadalavada, Nay Aung, Aaron Mark Lee, Nicholas C. Harvey, Tim Leiner, Calvin W.L. Chin, Matthias G. Friedrich, Andrea Barison, Marcus Dörr, Steffen E. Petersen
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Summary:Background - The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care. - Objectives - This paper provides age-, sex-, and ethnicity-specific CMR reference ranges for atrial and ventricular metrics from the Healthy Hearts Consortium, an international collaborative comprising 9,088 CMR studies from verified healthy individuals, covering the complete adult age spectrum across both sexes, and with the highest ethnic diversity reported to date. - Methods - CMR studies were analyzed using certified software with batch processing capability (cvi42, version 5.14 prototype, Circle Cardiovascular Imaging) by 2 expert readers. Three segmentation methods (smooth, papillary, anatomic) were used to contour the endocardial and epicardial borders of the ventricles and atria from long- and short-axis cine series. Clinically established ventricular and atrial metrics were extracted and stratified by age, sex, and ethnicity. Variations by segmentation method, scanner vendor, and magnet strength were examined. Reference ranges are reported as 95% prediction intervals. - Results - The sample included 4,452 (49.0%) men and 4,636 (51.0%) women with average age of 61.1 ± 12.9 years (range: 18-83 years). Among these, 7,424 (81.7%) were from White, 510 (5.6%) South Asian, 478 (5.3%) mixed/other, 341 (3.7%) Black, and 335 (3.7%) Chinese ethnicities. Images were acquired using 1.5-T (n = 8,779; 96.6%) and 3.0-T (n = 309; 3.4%) scanners from Siemens (n = 8,299; 91.3%), Philips (n = 498; 5.5%), and GE (n = 291, 3.2%). - Conclusions - This work represents a resource with healthy CMR-derived volumetric reference ranges ready for clinical implementation.
Item Description:Online veröffentlicht: 10. April 2024, Artikelversion: 1. Juli 2024
Gesehen am 17.02.2025
Physical Description:Online Resource
ISSN:1876-7591
DOI:10.1016/j.jcmg.2024.01.009

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