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The influence of contrast media on calcium-based imaging of the spine in dual-layer CT

This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, t...

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Main Authors: Rahn, Stefanie (Author) , Skornitzke, Stephan (Author) , Melzig, Claudius (Author) , Reiner, Tobias (Author) , Stiller, Wolfram (Author) , Heußel, Claus Peter (Author) , Kauczor, Hans-Ulrich (Author) , Weber, Tim (Author) , Do, Thuy (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2024
In: Scientific reports
Year: 2024, Volume: 14, Pages: 1-10
ISSN:2045-2322
DOI:10.1038/s41598-024-69743-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-024-69743-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-024-69743-3
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Author Notes:S. Rahn, S. Skornitzke, C. Melzig, T. Reiner, W. Stiller, C.P. Heussel, H.U. Kauczor, T.F. Weber & T.D. Do
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Summary:This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, true non-contrast (TNC) and venous phase images (VP) of n = 97 patients were acquired. CT attenuation of the first lumbar vertebra (L1) was measured in TNC-VCa, VP-VCa, and in virtual non-contrast images (VNC). CT attenuation was significantly higher in VP-VCa than in TNC-VCa (p < 0.001), although regression analyses revealed a strong linear association between these measures (R2 = 0.84). A statistical model for the prediction of TNC-VCa CT attenuation was established (TNC-VCa[HU] = − 6.81 + 0.87 × VP-VCa[HU]-0.55 × body weight[kg]) and yielded good agreement between observed and predicted values. Furthermore, a L1 CT attenuation threshold of 293 HU in VP-VCa showed a sensitivity of 90% and a specificity of 96% for detecting osteoporosis. The application of contrast media leads to an overestimation of L1 CT attenuation in VCa. However, CT attenuation values from VP-VCa can be used within CT-based opportunistic osteoporosis screening eighter by applying a separate threshold of 293 HU or by converting measured data to TNC-VCa CT attenuation with the given regression equation.
Item Description:Gesehen am 17.02.2025
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-024-69743-3

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