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Time course of the interaction between oral short-term ritonavir therapy with three factor Xa inhibitors and the activity of CYP2D6, CYP2C19, and CYP3A4 in healthy volunteers

We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with nirmatrelvir/ritonavir, on the pharmacokinetics of three factor Xa inhibitors (FXaI). Concurrently, the time course of the activities of the cytochromes P450 (CYP) 3A4, 2C19, and 2D6 was...

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Main Authors: Rohr, Brit Silja (Author) , Krohmer, Evelyn (Author) , Foerster, Kathrin (Author) , Burhenne, Jürgen (Author) , Schulz, Martin (Author) , Blank, Antje (Author) , Mikus, Gerd (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 23 February 2024
In: Clinical pharmacokinetics
Year: 2024, Volume: 63, Issue: 4, Pages: 469-481
ISSN:1179-1926
DOI:10.1007/s40262-024-01350-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s40262-024-01350-x
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Author Notes:Brit S. Rohr, Evelyn Krohmer, Kathrin I. Foerster, Jürgen Burhenne, Martin Schulz, Antje Blank, Gerd Mikus, Walter E. Haefeli
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Summary:We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with nirmatrelvir/ritonavir, on the pharmacokinetics of three factor Xa inhibitors (FXaI). Concurrently, the time course of the activities of the cytochromes P450 (CYP) 3A4, 2C19, and 2D6 was assessed.
Item Description:Gesehen am 18.02.2025
Physical Description:Online Resource
ISSN:1179-1926
DOI:10.1007/s40262-024-01350-x

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