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Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation

Advances in hematopoietic cell transplantation have expanded the use of alternative donors such as haploidentical family donors or mismatched unrelated donors. However, donor-specific HLA antibodies (DSA) have been recognized as a significant risk factor of primary graft failure after HLA incompatib...

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Main Authors: Tran, Thuong Hien (Author) , Heinold, Andreas (Author) , Spackova, Magdalena (Author) , Pham, Lien (Author) , Stelljes, Matthias (Author) , Dreger, Peter (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Best practice & research
Year: 2024, Volume: 37, Issue: 3, Pages: 1-12
ISSN:1532-1924
DOI:10.1016/j.beha.2024.101576
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.beha.2024.101576
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1521692624000422
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Author Notes:Thuong Hien Tran, Andreas Heinold, Magdalena Spackova, Lien Pham, Matthias Stelljes, Peter Dreger
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Summary:Advances in hematopoietic cell transplantation have expanded the use of alternative donors such as haploidentical family donors or mismatched unrelated donors. However, donor-specific HLA antibodies (DSA) have been recognized as a significant risk factor of primary graft failure after HLA incompatible transplantation. Therefore, screening for HLA antibodies and taking DSA into consideration in the process of donor search play an increasingly important role in donor selection. If an HLA compatible donor is not available, desensitization may enable a successful transplantation. In this review, we describe the currently most widely used methods for HLA antibody detections including their pitfalls. In addition, we summarize the results of the studies on the impact of preformed DSA on transplant outcomes and their treatment options. Many more and larger studies are needed to clarify laboratory issues as well as immunological and clinical aspects in the management of DSA.
Item Description:Gesehen am 25.02.2025
Online verfügbar: 28. August 2024, Artikelversion: 31. August 2024
Physical Description:Online Resource
ISSN:1532-1924
DOI:10.1016/j.beha.2024.101576

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