Iron scavenging and myeloid cell polarization
Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis and inflammation and are frequently characterized by their roles in either regulating or promoting inflammation....
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2024
|
| In: |
Trends in immunology
Year: 2024, Volume: 45, Issue: 8, Pages: 625-638 |
| ISSN: | 1471-4981 |
| DOI: | 10.1016/j.it.2024.06.006 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.it.2024.06.006 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1471490624001558 
|
| Author Notes: | Natalie Ludwig, Stefania Cucinelli, Simon Hametner, Martina U. Muckenthaler, and Lucas Schirmer |
| Summary: | Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis and inflammation and are frequently characterized by their roles in either regulating or promoting inflammation. Recent studies in cultured cells and mouse models highlight the role of iron in skewing the functional properties of myeloid cells in tissue damage and repair. Here, we review certain emerging concepts on how iron influences and determines myeloid cell polarization in the context of its uptake, storage, and metabolism, including in conditions such as multiple sclerosis (MS), sickle cell disease, and tumors. |
|---|---|
| Item Description: | Online verfügbar: 24. Juli 2024, Artikelversion: 8. August 2024 Gesehen am 25.02.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1471-4981 |
| DOI: | 10.1016/j.it.2024.06.006 |