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An arms-race against resistance: leukemic stem cells and lineage plasticity

Acute myeloid leukemia (AML) therapy is undergoing rapid development, but primary and acquired resistance to therapy complicates the prospect of a durable cure. Recent functional and single-cell multi-omics approaches have greatly expanded our knowledge of the diversity of lineage trajectories in AM...

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Main Authors: Waclawiczek, Alexander (Author) , Leppä, Aino-Maija (Author) , Renders, Simon (Author) , Trumpp, Andreas (Author)
Format: Article (Journal)
Language:English
Published: March 2024
In: Molecular oncology
Year: 2024, Volume: 18, Issue: 3, Pages: 475-478
ISSN:1878-0261
DOI:10.1002/1878-0261.13606
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/1878-0261.13606
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.13606
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Author Notes:Alexander Waclawiczek, Aino-Maija Leppä, Simon Renders, Andreas Trumpp
Description
Summary:Acute myeloid leukemia (AML) therapy is undergoing rapid development, but primary and acquired resistance to therapy complicates the prospect of a durable cure. Recent functional and single-cell multi-omics approaches have greatly expanded our knowledge of the diversity of lineage trajectories in AML settings. AML cells range from undifferentiated stem-like cells to more differentiated myeloid or megakaryocyte/erythroid cells. Current clinically relevant drugs predominantly target the myeloid progenitor lineage, while monocyte- or stem cell-like states can evade current AML treatment and may be targeted in the future with lineage-specific inhibitors. The extent of aberrant lineage plasticity upon therapeutic pressure in AML cells in conjunction with hijacking of normal differentiation pathways is still a poorly understood topic. Insights into the mechanisms of lineage plasticity of AML stem cells could identify both therapy-specific and cross-drug resistance pathways and reveal novel strategies to overcome them.
Item Description:Online veröffentlicht: 20. Februar 2024
Gesehen am 27.02.2025
Physical Description:Online Resource
ISSN:1878-0261
DOI:10.1002/1878-0261.13606

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