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Replication kinetics of pathogenic Eurasian orthohantaviruses in human mesangial cells

Eurasian pathogenic orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by acute kidney injury (AKI). The virulence of orthohantaviruses varies enormously and direct infection of different renal cell types contribute to pathogenesis. Glomerular mesangial cells play an...

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Main Authors: Boegelein, Lukas (Author) , Schreiber, Pamela (Author) , Philipp, Alexandra (Author) , Nußhag, Christian (Author) , Eßbauer, Sandra (Author) , Zeier, Martin (Author) , Krautkrämer, Ellen (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Virology journal
Year: 2024, Volume: 21, Pages: 1-10
ISSN:1743-422X
DOI:10.1186/s12985-024-02517-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12985-024-02517-5
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Author Notes:Lukas Boegelein, Pamela Schreiber, Alexandra Philipp, Christian Nusshag, Sandra Essbauer, Martin Zeier and Ellen Krautkrämer
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Summary:Eurasian pathogenic orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by acute kidney injury (AKI). The virulence of orthohantaviruses varies enormously and direct infection of different renal cell types contribute to pathogenesis. Glomerular mesangial cells play an essential role in the interplay between kidney cells and proper kidney function. Therefore, we analyzed the replication competence of different orthohantavirus species in primary mesangial cells and a mesangial cell line.
Item Description:Online veröffentlicht: 1. Oktober 2024
Gesehen am 04.03.2025
Physical Description:Online Resource
ISSN:1743-422X
DOI:10.1186/s12985-024-02517-5

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