Autoantibodies targeting nephrin in podocytopathies

Antinephrin autoantibodies occur in adults with minimal change disease and children with idiopathic nephrotic syndrome and appear to be disease activity markers. Their binding at slit diaphragms may induce podocyte dysfunction.

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Bibliographic Details
Main Authors:	Hengel, Felicitas Eugenia (Author) , Dehde, Silke (Author) , Lassé, Moritz (Author) , Zahner, Gunther (Author) , Seifert, Larissa (Author) , Schnarre, Annabel (Author) , Kretz, Oliver (Author) , Demir, Fatih (Author) , Pinnschmidt, Hans O. (Author) , Grahammer, Florian (Author) , Lucas, Renke (Author) , Mehner, Lea Maxima (Author) , Zimmermann, Tom (Author) , Billing, Anja M. (Author) , Oh, Jun (Author) , Mitrotti, Adele (Author) , Pontrelli, Paola (Author) , Debiec, Hanna (Author) , Dossier, Claire (Author) , Colucci, Manuela (Author) , Emma, Francesco (Author) , Smoyer, William E. (Author) , Weins, Astrid (Author) , Schaefer, Franz (Author) , Alachkar, Nada (Author) , Diemert, Anke (Author) , Hogan, Julien (Author) , Hoxha, Elion (Author) , Wiech, Thorsten (Author) , Rinschen, Markus M. (Author) , Ronco, Pierre (Author) , Vivarelli, Marina (Author) , Gesualdo, Loreto (Author) , Tomas, Nicola M. (Author) , Huber, Tobias B. (Author)
Format:	Article (Journal)
Language:	English
Published:	May 25, 2024
In:	The New England journal of medicine Year: 2024, Volume: 391, Issue: 5, Pages: 422-433
ISSN:	1533-4406
DOI:	10.1056/NEJMoa2314471
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2314471 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2314471
Author Notes:	Felicitas E. Hengel, Silke Dehde, Moritz Lassé, Gunther Zahner, Larissa Seifert, Annabel Schnarre, Oliver Kretz, Fatih Demir, Hans O. Pinnschmidt, Florian Grahammer, Renke Lucas, Lea Maxima Mehner, Tom Zimmermann, Anja M. Billing, Jun Oh, Adele Mitrotti, Paola Pontrelli, Hanna Debiec, Claire Dossier, Manuela Colucci, Francesco Emma, William E. Smoyer, Astrid Weins, Franz Schaefer, Nada Alachkar, Anke Diemert, Julien Hogan, Elion Hoxha, Thorsten Wiech, Markus M. Rinschen, Pierre Ronco, Marina Vivarelli, Loreto Gesualdo, Nicola M. Tomas, and T.B. Huber, for the International Society of Glomerular Disease

Description
Summary:	Antinephrin autoantibodies occur in adults with minimal change disease and children with idiopathic nephrotic syndrome and appear to be disease activity markers. Their binding at slit diaphragms may induce podocyte dysfunction.
Item Description:	Gesehen am 12.03.2025
Physical Description:	Online Resource
ISSN:	1533-4406
DOI:	10.1056/NEJMoa2314471