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Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis

Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multice...

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Main Authors: Abu Rumeileh, Samir (Author) , Scholle, Leila (Author) , Mensch, Alexander (Author) , Großkopf, Henning (Author) , Ratti, Antonia (Author) , Kölsch, Anna (Author) , Stoltenburg-Didinger, Gisela (Author) , Conrad, Julian (Author) , Gobbi, Anna de (Author) , Barba, Lorenzo (Author) , Steinacker, Petra (Author) , Klafki, Hans-Wolfgang (Author) , Oeckl, Patrick (Author) , Halbgebauer, Steffen (Author) , Stapf, Caroline Deborah (Author) , Posa, Andreas (Author) , Kendzierski, Thomas (Author) , Silani, Vincenzo (Author) , Hausner, Lucrezia (Author) , Ticozzi, Nicola (Author) , Frölich, Lutz (Author) , Weishaupt, Jochen H. (Author) , Verde, Federico (Author) , Otto, Markus (Author)
Format: Article (Journal)
Language:English
Published: 05 March 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-13
ISSN:2041-1723
DOI:10.1038/s41467-025-57144-7
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-57144-7
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-57144-7
Resolving-System, kostenfrei, Volltext: https://doi.org/10.25673/119005
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Author Notes:Samir Abu-Rumeileh, Leila Scholle, Alexander Mensch, Henning Großkopf, Antonia Ratti, Anna Kölsch, Gisela Stoltenburg-Didinger, Julian Conrad, Anna De Gobbi, Lorenzo Barba, Petra Steinacker, Hans-Wolfgang Klafki, Patrick Oeckl, Steffen Halbgebauer, Caroline Stapf, Andreas Posa, Thomas Kendzierski, Vincenzo Silani, Lucrezia Hausner, Nicola Ticozzi, Lutz Froelich, Jochen Hans Weishaupt, Federico Verde & Markus Otto
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Summary:Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.
Item Description:Gesehen am 31.07.2025
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-57144-7

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