Reconstitution and molecular characterisation of the mitochondrial membrane contact site
Due to their endosymbiotic origin, mitochondria of eukaryotic cells are enveloped by two membranes. While the outer membrane is rather flat, the inner membrane is intricately folded into subcompartments called cristae. Cristae are essential for efficient cellular respiration and for tight control of...
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| Formato: | Book/Monograph Tesis |
| Lenguaje: | inglés |
| Publicado: |
Göttingen
2025
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| Notas de Autor: | submitted by Barbora Turpin Knotkova ; first reviewer: Prof. Dr. Michael Meinecke, second reviewer: Prof. Dr. Silvio Rizzoli |
| Sumario: | Due to their endosymbiotic origin, mitochondria of eukaryotic cells are enveloped by two membranes. While the outer membrane is rather flat, the inner membrane is intricately folded into subcompartments called cristae. Cristae are essential for efficient cellular respiration and for tight control of apoptotic signalling, but the formation and maintenance of crista architecture is only poorly understood on a molecular level. A known key player in the upkeep of cristae is the MICOS complex, a multi-subunit protein complex situated at crista junctions. Deletions of MICOS subunits lead to aberr... |
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