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A neuroradiologist’s guide to operationalizing the response assessment in neuro-oncology (RANO) criteria version 2.0 for gliomas in adults

SUMMARY: Radiographic assessment plays a crucial role in the management of patients with central nervous system (CNS) tumors, aiding in treatment planning and evaluation of therapeutic efficacy by quantifying response. Recently, an updated version of the Response Assessment in Neuro-Oncology (RANO)...

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Main Authors: Ellingson, Ben (Author) , Sanvito, Francesco (Author) , Cloughesy, Timothy F. (Author) , Huang, Raymond Y. (Author) , Villanueva-Meyer, Javier E. (Author) , Pope, Whitney B. (Author) , Barboriak, Daniel P. (Author) , Shankar, Lalitha K. (Author) , Smits, Marion (Author) , Kaufmann, Timothy J. (Author) , Boxerman, Jerrold L. (Author) , Weller, Michael (Author) , Galanis, Evanthia (Author) , Groot, John de (Author) , Gilbert, Mark R. (Author) , Lassman, Andrew B. (Author) , Shiroishi, Mark S. (Author) , Nabavizadeh, Ali (Author) , Mehta, Minesh (Author) , Stupp, Roger (Author) , Wick, Wolfgang (Author) , Reardon, David A. (Author) , Vogelbaum, Michael A. (Author) , Bent, Martin van den (Author) , Chang, Susan M. (Author) , Wen, Patrick Y. (Author)
Format: Article (Journal)
Language:English
Published: December 9, 2024
In: American journal of neuroradiology
Year: 2024, Volume: 45, Issue: 12, Pages: 1846-1856
ISSN:1936-959X
DOI:10.3174/ajnr.A8396
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3174/ajnr.A8396
Verlag, lizenzpflichtig, Volltext: https://www.ajnr.org/content/45/12/1846
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Author Notes:Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang, and Patrick Y. Wen
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Summary:SUMMARY: Radiographic assessment plays a crucial role in the management of patients with central nervous system (CNS) tumors, aiding in treatment planning and evaluation of therapeutic efficacy by quantifying response. Recently, an updated version of the Response Assessment in Neuro-Oncology (RANO) criteria (RANO 2.0) was developed to improve upon prior criteria and provide an updated, standardized framework for assessing treatment response in clinical trials for gliomas in adults. This article provides an overview of significant updates to the criteria including (1) the use of a unified set of criteria for high and low grade gliomas in adults; (2) the use of the post-radiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas; (3) the option for the trial to mandate a confirmation scan to more reliably distinguish pseudoprogression from tumor progression; (4) the option of using volumetric tumor measurements; and (5) the removal of subjective non-enhancing tumor evaluations in predominantly enhancing gliomas (except for specific therapeutic modalities). Step-by-step pragmatic guidance is hereby provided for the neuroradiologist and imaging core lab involved in operationalization and technical execution of RANO 2.0 in clinical trials, including the display of representative cases and in-depth discussion of challenging scenarios.
Item Description:Gesehen am 17.03.2025
Physical Description:Online Resource
ISSN:1936-959X
DOI:10.3174/ajnr.A8396

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