Spark in the darkness: Discovering action potentials in brain tumors
Gliomas exhibit significant molecular diversity and poor prognosis. In this issue of Cancer Cell, Curry et al. apply Patch-seq on human glioma samples uncovering hybrid cells with glial and neuronal features, capable of firing action potentials in isocitrate dehydrogenase mutant gliomas. These findi...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 14, 2024
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| In: |
Cancer cell
Year: 2024, Volume: 42, Issue: 10, Pages: 1645-1647 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2024.09.004 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2024.09.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610824003520 
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| Author Notes: | Nikolas Andreas Stevens, Nina Drewa, Varun Venkataramani |
| Summary: | Gliomas exhibit significant molecular diversity and poor prognosis. In this issue of Cancer Cell, Curry et al. apply Patch-seq on human glioma samples uncovering hybrid cells with glial and neuronal features, capable of firing action potentials in isocitrate dehydrogenase mutant gliomas. These findings highlight the importance of neural features in tumor biology and progression. |
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| Item Description: | Gesehen am 17.03.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2024.09.004 |