Carbon ion mono-energetic and spread-out Bragg peak measurements using nanocomposite Fricke gel dosimeters with LET-independent response
This study investigates the LET-dependence of dose measurements performed with a nanocomposite Fricke gel (NC-FG) upon irradiation with carbon ion beams to address the problem of quenching of gel dosimeters in high-LET particle therapy. The preparation of the NC-FG in a simple gel preparation device...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 2024
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| In: |
Radiation measurements
Year: 2024, Jahrgang: 176, Pages: [1]-8 |
| ISSN: | 1879-0925 |
| DOI: | 10.1016/j.radmeas.2024.107175 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radmeas.2024.107175 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1350448724001239 
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| Verfasserangaben: | Viktoria Bayer, José Vedelago, Stefan Dorsch, Cedric Beyer, Stephan Brons, Wibke Johnen, Philipp Biegger, Ulrich Weber, Armin Runz, Christian P. Karger |
| Zusammenfassung: | This study investigates the LET-dependence of dose measurements performed with a nanocomposite Fricke gel (NC-FG) upon irradiation with carbon ion beams to address the problem of quenching of gel dosimeters in high-LET particle therapy. The preparation of the NC-FG in a simple gel preparation device was performed for atmospheric and anoxic environmental conditions and two different container materials. Irradiation was performed with carbon ion beams at energies of 133.39MeV/u or 194.87MeV/u, complemented by a modulated 10 mm carbon ion spread-out Bragg peak (SOBP) irradiation. The R1 profiles obtained from the MRI readout were compared to the treatment planning system and a 2D-ionisation chamber array measurement performed for the mono-energetic and SOBP irradiations, respectively. For different dose levels, no difference in the gel response was obtained for the 3D-printed plastic containers, while the glass vials exhibited a linear dose response. Additional use of the glove box changes produced similar results. For both the mono-energetic and the SOBP irradiation, a linear dose response without quenching was observed. For depths ranging up to the Bragg peak position, the mono-energetic profiles deviated by less than ± 15% from the planned dose distribution, excluding the lowest entrance surface dose (ESD). For the SOBP profiles, the deviation from the measured dose distribution was less than ± 10% for depths between 20 mm and 33 mm. This study presents a LET-independent measurement of mono-energetic carbon ion Bragg peaks and, for the first time, a LET-independent measurement of a carbon ion SOBP with the NC-FG prepared in a simple gel preparation device under atmospheric conditions. The NC-FG provides a possible solution for 3D dosimetry in carbon ion radiotherapy. |
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| Beschreibung: | Gesehen am 26.03.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1879-0925 |
| DOI: | 10.1016/j.radmeas.2024.107175 |