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Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis

Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This limits their performance as sepsis biomarkers in critically ill patien...

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Main Authors: Günther, Tobias (Author) , Coulibaly, Anna (Author) , Velásquez, Sonia Y. (Author) , Schulte, Jutta (Author) , Fuderer, Tanja (Author) , Sturm, Timo (Author) , Hahn, Bianka (Author) , Thiel, Manfred (Author) , Lindner, Holger A. (Author)
Format: Article (Journal)
Language:English
Published: 21 October 2024
In: Journal of Inflammation
Year: 2024, Volume: 21, Pages: 1-15
ISSN:1476-9255
DOI:10.1186/s12950-024-00414-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12950-024-00414-w
Verlag, kostenfrei, Volltext: https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-024-00414-w
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Author Notes:Tobias Guenther, Anna Coulibaly, Sonia Y. Velásquez, Jutta Schulte, Tanja Fuderer, Timo Sturm, Bianka Hahn, Manfred Thiel and Holger A. Lindner
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Summary:Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This limits their performance as sepsis biomarkers in critically ill patients. We hypothesized that activation of these pathways in sepsis is attributable to immature low-density (LD) rather than mature high-density (HD) granulocytes.
Item Description:Gesehen am 26.03.2025
Physical Description:Online Resource
ISSN:1476-9255
DOI:10.1186/s12950-024-00414-w

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