Buchumschlag

Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis

Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This limits their performance as sepsis biomarkers in critically ill patien...

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Hauptverfasser: Günther, Tobias (VerfasserIn) , Coulibaly, Anna (VerfasserIn) , Velásquez, Sonia Y. (VerfasserIn) , Schulte, Jutta (VerfasserIn) , Fuderer, Tanja (VerfasserIn) , Sturm, Timo (VerfasserIn) , Hahn, Bianka (VerfasserIn) , Thiel, Manfred (VerfasserIn) , Lindner, Holger A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 October 2024
In: Journal of Inflammation
Year: 2024, Jahrgang: 21, Pages: 1-15
ISSN:1476-9255
DOI:10.1186/s12950-024-00414-w
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12950-024-00414-w
Verlag, kostenfrei, Volltext: https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-024-00414-w
Volltext
Verfasserangaben:Tobias Guenther, Anna Coulibaly, Sonia Y. Velásquez, Jutta Schulte, Tanja Fuderer, Timo Sturm, Bianka Hahn, Manfred Thiel and Holger A. Lindner
Beschreibung
Zusammenfassung:Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This limits their performance as sepsis biomarkers in critically ill patients. We hypothesized that activation of these pathways in sepsis is attributable to immature low-density (LD) rather than mature high-density (HD) granulocytes.
Beschreibung:Gesehen am 26.03.2025
Beschreibung:Online Resource
ISSN:1476-9255
DOI:10.1186/s12950-024-00414-w

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