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Regional adoptive immunotherapy with interleukin-2 and lymphokine-activated killer (LAK) cells for liver metastases

A phase lb trial of a novel regional approach to adoptive immunotherapy is reported. Patients with liver metastases received continuous high-dose infusion of interleukin-2 (IL-2) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine-activated killer (LAK) cells into...

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Bibliographic Details
Main Authors: Keilholz, Ulrich (Author) , Scheibenbogen, Carmen (Author) , Brado, Matthias (Author) , Georgi, Peter (Author) , Maclachlan, David (Author) , Brado, Bernadett (Author) , Hunstein, Werner (Author)
Format: Article (Journal)
Language:English
Published: 1994
In: European journal of cancer
Year: 1994, Volume: 30, Issue: 1, Pages: 103-105
ISSN:1879-0852
DOI:10.1016/S0959-8049(05)80028-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0959-8049(05)80028-0
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804905800280
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Author Notes:Ulrich Keilholz, Carmen Scheibenbogen, Mathias Brado, Peter Georgi, David Maclachlan, Bernadett Brado and Werner Hunstein
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Summary:A phase lb trial of a novel regional approach to adoptive immunotherapy is reported. Patients with liver metastases received continuous high-dose infusion of interleukin-2 (IL-2) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine-activated killer (LAK) cells into the portal vein or the hepatic artery. Trafficking studies revealed homogenous distribution of the LAK cells within the liver. The usual side-effects of IL-2 and LAK cells occurred without limiting liver toxicity. One partial (7+ months) and two complete responses (36 and 26+ months) were observed in 9 patients with metastases from cutaneous melanoma. None of 6 patients with metastases from ocular melanoma responded.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 21. November 2005
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Falsche Namensform in der Verfasserangabe. Richtig: Brado, Matthias
Physical Description:Online Resource
ISSN:1879-0852
DOI:10.1016/S0959-8049(05)80028-0

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