Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer

The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other his...

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Main Authors: Stögbauer, Fabian (Author) , Beck, Susanne (Author) , Ourailidis, Iordanis (Author) , Heß, Jochen (Author) , Poremba, Christopher (Author) , Lauterbach, Maren (Author) , Wollenberg, Barbara (Author) , Buchberger, Anna Maria Stefanie (Author) , Jesinghaus, Moritz (Author) , Schirmacher, Peter (Author) , Stenzinger, Albrecht (Author) , Weichert, Wilko (Author) , Boxberg, Melanie (Author) , Budczies, Jan (Author)
Format: Article (Journal)
Language:English
Published: 12 April 2023
In: British journal of cancer
Year: 2023, Volume: 128, Issue: 12, Pages: 2295-2306
ISSN:1532-1827
DOI:10.1038/s41416-023-02240-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41416-023-02240-y
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-023-02240-y
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Author Notes:Fabian Stögbauer, Susanne Beck, Iordanis Ourailidis, Jochen Hess, Christopher Poremba, Maren Lauterbach, Barbara Wollenberg, Anna Maria Stefanie Buchberger, Moritz Jesinghaus, Peter Schirmacher, Albrecht Stenzinger, Wilko Weichert, Melanie Boxberg and Jan Budczies
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Summary:The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated.
Item Description:Gesehen am 09.04.2025
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/s41416-023-02240-y