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A brave new framework for glioma drug development

Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Initial and repetitive tissue sampling plays a...

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Main Authors: Hotchkiss, Kelly M. (Author) , Karschnia, Philipp (Author) , Schreck, Karisa C. (Author) , Geurts, Marjolein (Author) , Cloughesy, Timothy F (Author) , Huse, Jason (Author) , Duke, Elizabeth S. (Author) , Lathia, Justin (Author) , Ashley, David M (Author) , Nduom, Edjah K. (Author) , Long, Georgina (Author) , Singh, Kirit (Author) , Chalmers, Anthony (Author) , Ahluwalia, Manmeet S (Author) , Heimberger, Amy (Author) , Bagley, Stephen (Author) , Todo, Tomoki (Author) , Verhaak, Roel (Author) , Kelly, Patrick D (Author) , Hervey-Jumper, Shawn (Author) , de Groot, John (Author) , Patel, Anoop (Author) , Fecci, Peter (Author) , Parney, Ian (Author) , Wykes, Victoria (Author) , Watts, Colin (Author) , Burns, Terry C (Author) , Sanai, Nader (Author) , Preusser, Matthias (Author) , Tonn, Joerg Christian (Author) , Drummond, Katharine J (Author) , Platten, Michael (Author) , Das, Sunit (Author) , Tanner, Kirk (Author) , Vogelbaum, Michael A (Author) , Weller, Michael (Author) , Whittle, James R. (Author) , Berger, Mitchel S. (Author) , Khasraw, Mustafa (Author)
Format: Article (Journal)
Language:English
Published: October 2024
In: The lancet. Oncology
Year: 2024, Volume: 25, Issue: 10, Pages: e512-e519
ISSN:1474-5488
DOI:10.1016/S1470-2045(24)00190-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/S1470-2045(24)00190-6
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1470204524001906
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Author Notes:Kelly M Hotchkiss, Philipp Karschnia, Karisa C Schreck, Marjolein Geurts, Timothy F Cloughesy, Jason Huse, Elizabeth S Duke, Justin Lathia, David M Ashley, Edjah K Nduom, Georgina Long, Kirit Singh, Anthony Chalmers, Manmeet S Ahluwalia, Amy Heimberger, Stephen Bagley, Tomoki Todo, Roel Verhaak, Patrick D Kelly, Shawn Hervey-Jumper, John de Groot, Anoop Patel, Peter Fecci, Ian Parney, Victoria Wykes, Colin Watts, Terry C Burns, Nader Sanai, Matthias Preusser, Joerg Christian Tonn, Katharine J Drummond, Michael Platten, Sunit Das, Kirk Tanner, Michael A Vogelbaum, Michael Weller, James R Whittle, Mitchel S Berger, Mustafa Khasraw
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Summary:Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Initial and repetitive tissue sampling plays a crucial role in enhancing our understanding of resistance mechanisms and vulnerabilities in brain tumour therapy. Standardising biopsy techniques and ensuring technical uniformity across institutions are vital for effective interinstitutional collaboration. Although liquid biopsy technologies hold promise, they are not yet ready to replace tissue analysis. Clear communication about the risks and benefits of biopsies is essential, particularly regarding potential postoperative deficits. Changes in mindset and neurosurgical culture are imperative to achieve much needed breakthroughs in the development of new, effective therapies for brain tumours.
Item Description:Online verfügbar: 30. September 2024, Artikelversion: 30. September 2024
Gesehen am 10.04.2025
Physical Description:Online Resource
ISSN:1474-5488
DOI:10.1016/S1470-2045(24)00190-6

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