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Lenticulostriatal ischemia shows relevant SSTR expression on PET/CT imaging using the novel SSTR-targeting peptide 18F-SiTATE: interesting images

A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18F-SiTATE was performed 2.5 months thereafter. The meningio...

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Main Authors: Kunte, Sophie Carina (Author) , Unterrainer, Lena M. (Author) , Kunz, Wolfgang G. (Author) , Winkelmann, Michael (Author) , Lindner, Simon (Author) , Jurkschat, Klaus (Author) , Wängler, Carmen (Author) , Wängler, Björn (Author) , Schirrmacher, Ralf (Author) , Bartenstein, Peter (Author) , Belka, Claus (Author) , Schichor, Christian (Author) , Albert, Nathalie L. (Author) , Unterrainer, Marcus (Author)
Format: Article (Journal) Editorial
Language:English
Published: December 2024
In: Clinical nuclear medicine
Year: 2024, Volume: 49, Issue: 12, Pages: e689-e690
ISSN:1536-0229
DOI:10.1097/RLU.0000000000005482
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RLU.0000000000005482
Verlag, lizenzpflichtig, Volltext: http://journals.lww.com/nuclearmed/abstract/2024/12000/lenticulostriatal_ischemia_shows_relevant_sstr.40.aspx
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Author Notes:Kunte, Sophie C. MD, Unterrainer, Lena M. MD, Kunz, Wolfgang G. MD, Winkelmann, Michael MD,Lindner, Simon Dr. rer. nat., Jurkschat, Klaus Dr. rer. nat., Wängler, Carmen Dr. rer. nat., Wängler, Björn Dr. rer. nat., Schirrmacher, Ralf Dr. rer. nat., Bartenstein, Peter MD; Belka, Claus MD, Schichor, Christian MD, Albert, Nathalie L. MD, Unterrainer, Marcus MD
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Summary:A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.
Item Description:Im Titel ist die Zahl 18 hochgestellt
Gesehen am 14.04.2025
Physical Description:Online Resource
ISSN:1536-0229
DOI:10.1097/RLU.0000000000005482

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