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Emotion regulation in self-injurious youth: a tale of two circuits

Two emotion regulation (ER) networks, the amygdala and ventral striatum (VS) circuits underpin defensive and reward processes related to non-suicidal self-injury (NSSI). Youth who engaged in non-suicidal self-injury behavior (NSSIB) and healthy controls either watched images passively (passive condi...

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Main Authors: Santana-Gonzalez, Carmen (Author) , Ranatunga, Janani (Author) , Nguyen, Giang (Author) , Greiskalns, Brianna (Author) , Das, Natasha (Author) , Lattimer, Evan (Author) , Maurice, Matthew (Author) , Yi, Gina (Author) , Zietlow, Anna-Lena (Author) , Eckstein, Monika (Author) , Zilverstand, Anna (Author) , Quevedo, Karina (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Psychiatry research. Neuroimaging
Year: 2025, Volume: 347, Pages: 1-12
ISSN:1872-7506
DOI:10.1016/j.pscychresns.2024.111944
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.pscychresns.2024.111944
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0925492724001677
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Author Notes:Carmen Santana-Gonzalez, Janani Ranatunga, Giang Nguyen, Brianna Greiskalns, Natasha Das, Evan Lattimer, Matthew Maurice, Gina Yi, Anna-Lena Zietlow, Monika Eckstein, Anna Zilverstand, Karina Quevedo
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Summary:Two emotion regulation (ER) networks, the amygdala and ventral striatum (VS) circuits underpin defensive and reward processes related to non-suicidal self-injury (NSSI). Youth who engaged in non-suicidal self-injury behavior (NSSIB) and healthy controls either watched images passively (passive condition) or increased their positive affect during positive/neutral images and decreased their negative affect during negative and self-harm images (regulate condition) in the scanner. NSSI youth showed higher amygdala to precuneus and inferior parietal lobe (IPL) connectivity while regulating emotions during self-harm images, a pattern which was associated with higher self-injury frequency. NSSI youth showed higher VS connectivity to the fusiform gyrus and parahippocampus while regulating emotions elicited by self-harm and positive images, which was in turn linked to higher self-harm frequency and relief after NSSI. Higher amygdala-precuneus and IPL connectivity in NSSI youth suggest greater self-identification with, or difficulty regulating negative affect elicited by, self-injury images. High VS-fusiform gyrus and parahippocampus connectivity during positive and self-harm images implies reward anomalies and/or greater effort to regulate positive affect. VS circuit's’ links to relief and NSSIB frequency suggest VS reward-based learning as biomarker of NSSIB endurance. We discovered ER mechanisms in adolescents with NSSIB and promising targets for effective NSSIB treatment.
Item Description:Online veröffentlicht: 18. Dezember 2024
Gesehen am 17.04.2025
Physical Description:Online Resource
ISSN:1872-7506
DOI:10.1016/j.pscychresns.2024.111944

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