Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting

The fibrinolytic system promotes the progression of solid tumors. Here, the authors show that the fibrinolytic agent plasmin supports B-cell acute lymphoblastic leukemia (B-ALL) progression via remodeling of the extracellular matrix, and the inhibition of plasmin activation with ε-aminocaproic acid...

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Main Authors:	Minciacchi, Valentina R. (Author) , Bravo, Jimena (Author) , Karantanou, Christina (Author) , Pereira, Raquel (Author) , Zanetti, Costanza (Author) , Kumar, Rahul (Author) , Thomasberger, Nathalie (Author) , Llavona Juez, Pablo (Author) , Krack, Theresa (Author) , Bankov, Katrin (Author) , Meister, Melanie (Author) , Hartmann, Sylvia (Author) , Maguer-Satta, Véronique (Author) , Lefort, Sylvain (Author) , Putyrski, Mateusz (Author) , Ernst, Andreas (Author) , Huntly, Brian J. P. (Author) , Meduri, Eshwar (Author) , Ruf, Wolfram (Author) , Krause, Daniela Sandra (Author)
Format:	Article (Journal)
Language:	English
Published:	20 November 2024
In:	Nature Communications Year: 2024, Volume: 15, Pages: 1-19
ISSN:	2041-1723
DOI:	10.1038/s41467-024-54361-4
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-54361-4 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-54361-4
Author Notes:	Valentina R. Minciacchi, Jimena Bravo, Christina Karantanou, Raquel S. Pereira, Costanza Zanetti, Rahul Kumar, Nathalie Thomasberger, Pablo Llavona, Theresa Krack, Katrin Bankov, Melanie Meister, Sylvia Hartmann, Véronique Maguer-Satta, Sylvain Lefort, Mateusz Putyrski, Andreas Ernst, Brian J. P. Huntly, Eshwar Meduri, Wolfram Ruf & Daniela S. Krause