Cover Image

The dose of granulocyte colony-stimulating factor administered following cytotoxic chemotherapy is not related to the rebound level of circulating CD34+ haemopoietic progenitor cells during marrow recovery

We report on the RmetHuG-CSF (filgrastim)-related mobilization efficiency in 120 patients with multiple myeloma who received cytotoxic chemotherapy. Three schedules of G-CSF administration starting 24 h after the end of chemotherapy were used: (1) a standard dose of 300 μg/d until the completion of...

Full description

Saved in:
Bibliographic Details
Main Authors: Martin, Simona (Author) , Voso, Maria Teresa (Author) , Hohaus, Stefan (Author) , Pförsich, Margit (Author) , Frühauf, Stefan (Author) , Goldschmidt, Hartmut (Author) , Hegenbart, Ute (Author) , Haas, Rainer (Author)
Format: Article (Journal)
Language:English
Published: June 1998
In: British journal of haematology
Year: 1998, Volume: 101, Issue: 3, Pages: 588-591
ISSN:1365-2141
DOI:10.1046/j.1365-2141.1998.00730.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.1998.00730.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.1998.00730.x
Get full text
Author Notes:S. Martin-Murea, M.T. Voso, S. Hohaus, M. Pförsich, S. Fruehauf, H. Goldschmidt, U. Hegenbart, and R. Haas
Description
Summary:We report on the RmetHuG-CSF (filgrastim)-related mobilization efficiency in 120 patients with multiple myeloma who received cytotoxic chemotherapy. Three schedules of G-CSF administration starting 24 h after the end of chemotherapy were used: (1) a standard dose of 300 μg/d until the completion of PBSC collection; (2) dose escalation from 300 to 600-1200 μg/d during marrow recovery; (3) 600 or 1200 μg/d starting 24 h after cytotoxic chemotherapy. As a result, the individual dose per kg bodyweight varied between 2.83 and 23.08 μg. No relationship was found between the dose of G-CSF administered and the peak level of circulating CD34+ cells or the CD34+ cell counts recorded over the entire collection period.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 25. Dezember 2001
Im Titel ist "+" hochgestellt
Gesehen am 23.04.2025
Physical Description:Online Resource
ISSN:1365-2141
DOI:10.1046/j.1365-2141.1998.00730.x

Similar Items