E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance

Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling.

Saved in:
Bibliographic Details
Main Authors: Lehmann, Janina A. (Author) , Lindner, Doris (Author) , Sung, Hsu-Min (Author) , Stoecklin, Georg (Author)
Format: Article (Journal)
Language:English
Published: 28 November 2024
In: Nature Communications
Year: 2024, Volume: 15, Pages: 1-14
ISSN:2041-1723
DOI:10.1038/s41467-024-54411-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-54411-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-54411-x
Get full text
Author Notes:Janina A. Lehmann, Doris Lindner, Hsu-Min Sung & Georg Stoecklin
Description
Summary:Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling.
Item Description:Gesehen am 23.04.2025
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-024-54411-x