E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance
Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling.
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 November 2024
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| In: |
Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-14 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-54411-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-54411-x Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-54411-x |
| Verfasserangaben: | Janina A. Lehmann, Doris Lindner, Hsu-Min Sung & Georg Stoecklin |
| Zusammenfassung: | Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling. |
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| Beschreibung: | Gesehen am 23.04.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-54411-x |