E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance
Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling.
Guardado en:
| Autores principales: | , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
28 November 2024
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| In: |
Nature Communications
Year: 2024, Volumen: 15, Pages: 1-14 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-54411-x |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-54411-x Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-54411-x 
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| Notas de Autor: | Janina A. Lehmann, Doris Lindner, Hsu-Min Sung & Georg Stoecklin |
| Sumario: | Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling. |
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| Notas: | Gesehen am 23.04.2025 |
| Descripción Física: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-54411-x |