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The role of the oral microbiota in the causal effect of adjunctive antibiotics on clinical outcomes in stage III-IV periodontitis patients

Periodontitis, a prevalent chronic inflammatory disease, offers insights into the broader landscape of chronic inflammatory conditions. The progression and treatment outcomes of periodontitis are closely related to the oral microbiota’s composition. Adjunctive systemic Amoxicillin 500 mg and Metroni...

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Main Authors: Kleine Bardenhorst, Sven (Author) , Hagenfeld, Daniel (Author) , Matern, Johannes (Author) , Prior, Karola (Author) , Harks, Inga (Author) , Eickholz, Peter (Author) , Lorenz, Katrin (Author) , Kim, Ti-Sun (Author) , Kocher, Thomas (Author) , Meyle, Jörg (Author) , Kaner, Doğan (Author) , Jockel-Schneider, Yvonne (Author) , Harmsen, Dag (Author) , Ehmke, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 26 October 2024
In: Microbiome
Year: 2024, Volume: 12, Pages: 1-12
ISSN:2049-2618
DOI:10.1186/s40168-024-01945-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40168-024-01945-3
Verlag, kostenfrei, Volltext: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01945-3
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Author Notes:Sven Kleine Bardenhorst, Daniel Hagenfeld, Johannes Matern, Karola Prior, Inga Harks, Peter Eickholz, Katrin Lorenz, Ti-Sun Kim, Thomas Kocher, Jörg Meyle, Doğan Kaner, Yvonne Jockel-Schneider, Dag Harmsen and Benjamin Ehmke
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Summary:Periodontitis, a prevalent chronic inflammatory disease, offers insights into the broader landscape of chronic inflammatory conditions. The progression and treatment outcomes of periodontitis are closely related to the oral microbiota’s composition. Adjunctive systemic Amoxicillin 500 mg and Metronidazole 400 mg, often prescribed thrice daily for 7 days to enhance periodontal therapy’s efficacy, have lasting effects on the oral microbiome. However, the precise mechanism through which the oral microbiome influences clinical outcomes in periodontitis patients remains debated. This investigation explores the pivotal role of the oral microbiome's composition in mediating the outcomes of adjunctive systemic antibiotic treatment.
Item Description:Gesehen am 23.04.2025
Physical Description:Online Resource
ISSN:2049-2618
DOI:10.1186/s40168-024-01945-3

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