Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage

The factor Xa inhibitor reversal agent andexanet reduced expansion of intracerebral hemorrhages caused by factor Xa inhibitors but resulted in more thrombotic events than usual care.

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Bibliographic Details
Main Authors:	Connolly, Stuart J. (Author) , Sharma, Mukul (Author) , Cohen, Alexander T. (Author) , Demchuk, Andrew M. (Author) , Członkowska, Anna (Author) , Lindgren, Arne G. (Author) , Molina, Carlos A. (Author) , Bereczki, Daniel (Author) , Toni, Danilo (Author) , Seiffge, David J. (Author) , Tanne, David (Author) , Sandset, Else Charlotte (Author) , Tsivgoulis, Georgios (Author) , Christensen, Hanne (Author) , Beyer-Westendorf, Jan (Author) , Coutinho, Jonathan M. (Author) , Crowther, Mark (Author) , Verhamme, Peter (Author) , Amarenco, Pierre (Author) , Roine, Risto O. (Author) , Mikulik, Robert (Author) , Lemmens, Robin (Author) , Veltkamp, Roland (Author) , Middeldorp, Saskia (Author) , Robinson, Thompson G. (Author) , Milling, Truman John (Author) , Tedim-Cruz, Vitor (Author) , Lang, Wilfried (Author) , Himmelmann, Anders (Author) , Ladenvall, Per (Author) , Knutsson, Mikael (Author) , Ekholm, Ella (Author) , Law, Andrew (Author) , Taylor, Amanda (Author) , Karyakina, Tetyana (Author) , Xu, Lizhen (Author) , Tsiplova, Kate (Author) , Poli, Sven (Author) , Kallmünzer, Bernd (Author) , Gumbinger, Christoph (Author) , Shoamanesh, Ashkan (Author)
Format:	Article (Journal)
Language:	English
Published:	May 16/23, 2024
In:	The New England journal of medicine Year: 2024, Volume: 390, Issue: 19, Pages: 1745-1755
ISSN:	1533-4406
DOI:	10.1056/NEJMoa2313040
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2313040 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2313040
Author Notes:	Stuart J. Connolly, Mukul Sharma, Alexander T. Cohen, Andrew M. Demchuk, Anna Członkowska, Arne G. Lindgren, Carlos A. Molina, Daniel Bereczki, Danilo Toni, David J. Seiffge, David Tanne, Else Charlotte Sandset, Georgios Tsivgoulis, Hanne Christensen, Jan Beyer-Westendorf, Jonathan M. Coutinho, Mark Crowther, Peter Verhamme, Pierre Amarenco, Risto O. Roine, Robert Mikulik, Robin Lemmens, Roland Veltkamp, Saskia Middeldorp, Thompson G. Robinson, Truman John Milling, Vitor Tedim-Cruz, Wilfried Lang, Anders Himmelmann, Per Ladenvall, Mikael Knutsson, Ella Ekholm, Andrew Law, Amanda Taylor, Tetyana Karyakina, Lizhen Xu, Kate Tsiplova, Sven Poli, Bernd Kallmünzer, Christoph Gumbinger, and Ashkan Shoamanesh, for the ANNEXA-I investigators

Description
Summary:	The factor Xa inhibitor reversal agent andexanet reduced expansion of intracerebral hemorrhages caused by factor Xa inhibitors but resulted in more thrombotic events than usual care.
Item Description:	"This article was updated on June 13, 2024, at NEJM.org" Online veröffentlicht: 15. Mai 2024 Gesehen am 23.04.2025
Physical Description:	Online Resource
ISSN:	1533-4406
DOI:	10.1056/NEJMoa2313040