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How do parents decide on genetic testing in pediatrics?: A systematic review

Purpose - This systematic review aims to identify the factors that influence parents’ decisions regarding pediatric diagnostic genetic testing (DT) and predictive genetic testing (PT). These factors are integrated into a conceptual decision-making model. Implications for genetic counseling, research...

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Main Authors: Doll, Elena Sophia (Author) , Lerch, Seraina Petra (Author) , Schmalenberger, Katja (Author) , Alex, Karla (Author) , Kölker, Stefan (Author) , Brennenstuhl, Heiko (Author) , Pereira, Stacey (Author) , Smith, Hadley S. (Author) , Winkler, Eva C. (Author) , Mahal, Julia (Author) , Ditzen, Beate (Author)
Format: Article (Journal)
Language:English
Published: 19 February 2025
In: Genetics in medicine
Year: 2025, Volume: 27, Issue: 5, Pages: 1-14
ISSN:1530-0366
DOI:10.1016/j.gim.2025.101390
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.gim.2025.101390
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1098360025000371
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Author Notes:Elena Sophia Doll, Seraina Petra Lerch, Katja Maria Schmalenberger, Karla Alex, Stefan Kölker, Heiko Brennenstuhl, Stacey Pereira, Hadley Smith, Eva Caroline Winkler, Julia Mahal, Beate Ditzen
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Summary:Purpose - This systematic review aims to identify the factors that influence parents’ decisions regarding pediatric diagnostic genetic testing (DT) and predictive genetic testing (PT). These factors are integrated into a conceptual decision-making model. Implications for genetic counseling, research, and ethics were derived. - Methods - PubMed, PsychInfo, WebofScience, and related references were searched for original publications between 2000 and 2023. The extracted factors were categorized using existing models. - Results - Of the 5843 publications, 56 met the inclusion criteria. The included studies differentiated between DT, traditional PT, and expanded PT and described factors affecting parental decisions to have the child genetically tested and to be informed about additional findings. Factors included (1) benefits/hopes, (2) worries/concerns, (3) values and beliefs, (4) individual circumstances, and (5) emotional states. - Conclusion - Our work extends the existing empirical decision model of family decisions about genome sequencing to genetic testing in pediatrics in general, adding the categories of individual circumstances and emotional states. These factors can be further integrated into the Health Belief Model; the importance of emotional states is reflected in dual-process theories, such as the Fuzzy Trace Theory. Research is required on emotional states, differences between DT and PT, parents’ decisions regarding result disclosure, and dyadic variables as decision-making predictors.
Item Description:Online verfügbar: 19. Februar 2025
Gesehen am 24.04.2025
Physical Description:Online Resource
ISSN:1530-0366
DOI:10.1016/j.gim.2025.101390

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