Risk of cellular or antibody-mediated rejection in pediatric kidney transplant recipients with BK polyomavirus replication: an international CERTAIN registry study

In kidney transplant recipients (KTR), BK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of graft loss. To facilitate the clearance of BKPyV-DNAemia, reduction of immunosuppression is currently the treatment of choice but may increase the risk of graft rejection.

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Main Authors: Fichtner, Alexander (Author) , Schmidt, Jeremy (Author) , Süsal, Caner (Author) , Carraro, Andrea (Author) , Oh, Jun (Author) , Zirngibl, Matthias (Author) , König, Sabine (Author) , Guzzo, Isabella (Author) , Weber, Lutz T. (Author) , Awan, Atif (Author) , Krupka, Kai (Author) , Schnitzler, Paul (Author) , Hirsch, Hans H. (Author) , Tönshoff, Burkhard (Author) , Höcker, Britta (Author)
Format: Article (Journal)
Language:English
Published: March 2025
In: Pediatric nephrology
Year: 2025, Volume: 40, Issue: 3, Pages: 835-848
ISSN:1432-198X
DOI:10.1007/s00467-024-06501-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00467-024-06501-7
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00467-024-06501-7
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Author Notes:Alexander Fichtner, Jeremy Schmidt, Caner Süsal, Andrea Carraro, Jun Oh, Matthias Zirngibl, Sabine König, Isabella Guzzo, Lutz T. Weber, Atif Awan, Kai Krupka, Paul Schnitzler, Hans H. Hirsch, Burkhard Tönshoff, Britta Höcker
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Summary:In kidney transplant recipients (KTR), BK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of graft loss. To facilitate the clearance of BKPyV-DNAemia, reduction of immunosuppression is currently the treatment of choice but may increase the risk of graft rejection.
Item Description:Online verfügbar: 11. Oktober 2024
Gesehen am 25.04.2025
Physical Description:Online Resource
ISSN:1432-198X
DOI:10.1007/s00467-024-06501-7