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Potassium levels and short-term outcomes in heart failure with mildly reduced ejection fraction

Objective - The study investigates the prognostic impact of dyskalemias in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). - Background - Although dyskalemias represent a common complication in patients with heart failure (HF) and reduced left ventricular eje...

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Main Authors: Reinhardt, Marielen (Author) , Behnes, Michael (Author) , Weidner, Kathrin (Author) , Ayasse, Niklas (Author) , Lau, Felix (Author) , Schmitt, Alexander (Author) , Abel, Noah (Author) , Dudda, Jonas (Author) , Bertsch, Thomas (Author) , Dürschmied, Daniel (Author) , Akın, Ibrahim (Author) , Schupp, Tobias (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2025
In: International journal of cardiology
Year: 2025, Volume: 421, Pages: 1-8
ISSN:1874-1754
DOI:10.1016/j.ijcard.2024.132878
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2024.132878
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527324015006
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Author Notes:Marielen Reinhardt, Michael Behnes, Kathrin Weidner, Niklas Ayasse, Felix Lau, Alexander Schmitt, Noah Abel, Jonas Dudda, Thomas Bertsch, Daniel Duerschmied, Ibrahim Akin, Tobias Schupp
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Summary:Objective - The study investigates the prognostic impact of dyskalemias in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). - Background - Although dyskalemias represent a common complication in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF), data concerning the prevalence and prognostic impact of dyskalemias in HFmrEF is limited. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. The prognostic impact of potassium levels was assessed comparing patients with potassium levels > 3.3 to ≤4.5 mmol/L, ≤3.3 mmol/L and > 4.5 mmol/L. The primary endpoint was all-cause mortality at 30 days. - Results - 2079 patients with HFmrEF and potassium measurement were included (median potassium level: 4.4 mmol/L; mean 4.2 mmol/L). 84 % of patients hospitalized with HFmrEF presented with potassium levels in the norm range, 8 % with hypokalemia and 8 % with hyperkalemia, respectively. The risk of all-cause mortality at 30 days was higher in patients with hyperkalemia compared to patients with normokalemia (7 % vs 4 %; log rank p = 0.026), whereas the presence of hypokalemia (6 %; log rank p = 0.075) was not significantly associated with the risk of 30-days all-cause mortality. Compared to patients with normokalemia, the presence of hyperkalemia was still associated with an increased risk of 30-day all-cause mortality within a multivariable Cox regression analysis (HR = 2.002; 95 % CI 1.004-3.992; p = 0.049). - Conclusion - In patients hospitalized with HFmrEF, hyperkalemia - but not hypokalemia - was independently associated with an increased risk of all-cause mortality at 30 days.
Item Description:Online verfügbar: 3. Dezember 2024, Artikelversion: 12. Dezember 2024
Gesehen am 29.04.2025
Physical Description:Online Resource
ISSN:1874-1754
DOI:10.1016/j.ijcard.2024.132878

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