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Amyloid-beta metabolism in age-related neurocardiovascular diseases

Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may indu...

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Main Authors: Aivalioti, Evmorfia (Author) , Georgiopoulos, Georgios (Author) , Tual-Chalot, Simon (Author) , Bampatsias, Dimitrios (Author) , Delialis, Dimitrios (Author) , Sopova, Kateryna (Author) , Drakos, Stavros G (Author) , Stellos, Konstantinos (Author) , Stamatelopoulos, Kimon (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2025
In: European heart journal
Year: 2025, Volume: 46, Issue: 3, Pages: 250-272
ISSN:1522-9645
DOI:10.1093/eurheartj/ehae655
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/eurheartj/ehae655
Verlag, kostenfrei, Volltext: https://academic.oup.com/eurheartj/article/46/3/250/7889342
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Author Notes:Evmorfia Aivalioti, Georgios Georgiopoulos, Simon Tual-Chalot, Dimitrios Bampatsias, Dimitrios Delialis, Kateryna Sopova, Stavros G. Drakos, Konstantinos Stellos, and Kimon Stamatelopoulos
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Summary:Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood-brain barrier function and vascular health in age-related diseases. Genetic-, age-, lifestyle- or cardiovascular therapy-associated imbalance of amyloid-beta (Aβ) peptide metabolism in the brain and periphery may be the missing link between age-related neurocardiovascular diseases. Genetic polymorphisms of genes related to Aβ metabolism, lifestyle modifications, drugs used in clinical practice, and Aβ-specific treatments may modulate Aβ levels, affecting brain, vascular, and cardiac diseases. This narrative review elaborates on the effects of interventions on Aβ metabolism in the brain, cerebrospinal fluid, blood, and peripheral heart or vascular tissues. Implications for clinical applicability, gaps in knowledge, and future perspectives of Aβ as the link among age-related neurocardiovascular diseases are also discussed.
Item Description:Online veröffentlicht: 11. November 2024
Gesehen am 30.04.2025
Physical Description:Online Resource
ISSN:1522-9645
DOI:10.1093/eurheartj/ehae655

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