Cover Image

Auto-contouring of cardiac substructures for stereotactic arrhythmia radioablation (STAR): a STOPSTORM.eu consortium study

Background/Purpose - High doses to healthy cardiac substructures (CS) in stereotactic arrhythmia radioablation (STAR) raise concerns regarding potential treatment-induced cardio-toxicity. However, CS contours are not routinely created, hindering the understanding of the CS dose-effect relationships....

Full description

Saved in:
Bibliographic Details
Main Authors: Van der Pol, Luuk (Author) , Blanck, Oliver (Author) , Grehn, Melanie (Author) , Blazek, Tomáš (Author) , Knybel, Lukáš (Author) , Balgobind, Brian V. (Author) , Verhoeff, Joost J. C. (Author) , Miszczyk, Marcin (Author) , Blamek, Slawomir (Author) , Reichl, Sabrina (Author) , Andratschke, Nicolaus (Author) , Mehrhof, Felix (Author) , Boda-Heggemann, Judit (Author) , Tomasik, Bartłomiej (Author) , Mandija, Stefano (Author) , Fast, Martin F. (Author)
Format: Article (Journal)
Language:English
Published: January 2025
In: Radiotherapy and oncology
Year: 2025, Volume: 202, Pages: 1-8
ISSN:1879-0887
DOI:10.1016/j.radonc.2024.110610
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radonc.2024.110610
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814024042725
Get full text
Author Notes:Luuk H.G. van der Pol, Oliver Blanck, Melanie Grehn, Tomáš Blazek, Lukáš Knybel, Brian V. Balgobind, Joost J.C. Verhoeff, Marcin Miszczyk, Slawomir Blamek, Sabrina Reichl, Nicolaus Andratschke, Felix Mehrhof, Judit Boda-Heggemann, Bartłomiej Tomasik, Stefano Mandija, Martin F. Fast
Description
Summary:Background/Purpose - High doses to healthy cardiac substructures (CS) in stereotactic arrhythmia radioablation (STAR) raise concerns regarding potential treatment-induced cardio-toxicity. However, CS contours are not routinely created, hindering the understanding of the CS dose-effect relationships. To address this issue, the alignment of CS contouring was initiated within the STOPSTORM consortium. In this study, we developed and evaluated auto-contouring models trained to delineate CS and major vessels in ventricular tachycardia (VT) patients. - Methods - Eight centres provided standard treatment planning computed tomography (CT) and/or contrast-enhanced CT datasets of 55 VT patients, each including 16 CS. Auto-contouring models were trained to contour either large structures or small structures. Dice Similarity Coefficient (DSC), 95 % Hausdorff distance (HD95) and volume ratio (VR) were used to evaluate model performance versus inter-observer variation (IOV) on seven VT patient test cases. Significant differences were tested using the Mann-Whitney U test. - Results - The performance on the four chambers and the major vessels (median DSC: 0.88; HD95: 5.8-19.4 mm; VR: 1.09) was similar to the IOV (median DSC: 0.89; HD95: 4.8-14.0 mm; VR: 1.20). For the valves, model performance (median DSC: 0.37; HD95: 11.6 mm; VR: 1.63) was similar to the IOV (median DSC: 0.41; HD95: 12.4 mm; VR: 3.42), but slightly worse for the coronary arteries (median DSC: 0.33 vs 0.42; HD95: 24.4 mm vs 16.9 mm; VR: 1.93 vs 3.30). The IOV for these small structures remains large despite using contouring guidelines. - Conclusion - CS auto-contouring models trained on VT patient data perform similarly to IOV. This allows for time-efficient evaluation of CS as possible organs-at-risk.
Item Description:Online verfügbar: 1. November 2024, Artikelversion: 6. November 2024
Gesehen am 13.05.2025
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2024.110610

Similar Items