Sarcopenia influences clinical outcome in hospitalized patients with peripheral artery disease aged 75 years and older
Background - Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD. - Methods - All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005-2020 in...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2025
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| In: |
Annals of vascular surgery
Year: 2025, Volume: 110, Issue: Part B, Pages: 54-65 |
| ISSN: | 1615-5947 |
| DOI: | 10.1016/j.avsg.2024.09.066 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.avsg.2024.09.066 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0890509624006629 
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| Author Notes: | Volker H. Schmitt, Lukas Hobohm, Christoph Brochhausen, Christine Espinola-Klein, Philipp Lurz, Thomas Münzel, Omar Hahad, and Karsten Keller, Mainzand and Heidelberg, Germany |
| Summary: | Background - Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD. - Methods - All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005-2020 in Germany were included in the study and stratified for sarcopenia. Temporal trends and the impact of sarcopenia on treatment procedures as well as adverse in-hospital events were investigated. - Results - Overall, 1,166,848 hospitalization cases of patients admitted due to PAD (median age 81.0 [78.0-85.0] years; 49.5% female sex) were included, of which 2,109 (0.2%) were coded with sarcopenia. Prevalence of sarcopenia in these patients increased during the observational period from 0.05% in 2005 to 0.34% in 2020 (β 2.61 [95%CI 2.42-2.80], P < 0.001). Sarcopenic PAD patients were more often female (52.1% vs. 49.5%, P = 0.015), obese (6.6% vs. 5.5%, P = 0.021), and revealed higher prevalences of comorbidities (Charlson comorbidity index, 7.00 [6.00-9.00] vs. 6.00 [5.00-7.00], P < 0.001). Sarcopenia was associated with reduced usage of reperfusion treatments (endovascular intervention: odds ratio (OR) 0.409 [95%CI 0.358-0.466], P < 0.001; surgical revascularization: OR 0.705 [95%CI 0.617-0.805], P < 0.001) but higher conduction of amputation (OR 1.365 [95%CI 1.231-1.514], P < 0.001) and higher rates of major adverse cardiovascular and cerebrovascular events (MACCE) (OR 1.313 [95%CI 1.141-1.512], P < 0.001) and in-hospital death (OR 1.229 [95%CI 1.052-1.436], P = 0.009). - Conclusions - Sarcopenia is an under-recognized condition in PAD patients of high clinical relevance causing a crucial disease burden. Awareness of the ailment needs to be increased in daily clinical practice to identify sarcopenia and improve the clinical outcome of this vulnerable patient group. |
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| Item Description: | Auf dem Titelblatt steht am Ende der Verantwortlichkeitsangabe "Mainzand" anstelle von Mainz Online verfügbar: 19. Oktober 2024, Artikelversion: 12. November 2024 Gesehen am 13.05.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1615-5947 |
| DOI: | 10.1016/j.avsg.2024.09.066 |