RV-PA uncoupling is associated with increased mortality in transthyretin amyloid cardiomyopathy treated with tafamidis
The right ventricle to pulmonary artery coupling (RV-PAc) describes the right ventricle’s ability to adjust to an increased afterload. In case of transthyretin amyloid cardiomyopathy (ATTR-CM), impaired RV-PAc can result from increased left ventricular diastolic stiffness due to fibril deposition.
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 November 2024
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| In: |
Clinical research in cardiology
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| ISSN: | 1861-0692 |
| DOI: | 10.1007/s00392-024-02576-2 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00392-024-02576-2 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00392-024-02576-2 |
| Author Notes: | Stéphanie K. Schwarting, Michael Poledniczek, Yuliyan Metodiev, Lukas Stolz, Eva Hofmann, Ute Hegenbart, Stefan Schönland, Stefan Kääb, Steffen Massberg, Norbert Frey, Fabian aus dem Siepen |
| Summary: | The right ventricle to pulmonary artery coupling (RV-PAc) describes the right ventricle’s ability to adjust to an increased afterload. In case of transthyretin amyloid cardiomyopathy (ATTR-CM), impaired RV-PAc can result from increased left ventricular diastolic stiffness due to fibril deposition. |
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| Item Description: | Gesehen am 16.05.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1861-0692 |
| DOI: | 10.1007/s00392-024-02576-2 |