RV-PA uncoupling is associated with increased mortality in transthyretin amyloid cardiomyopathy treated with tafamidis

The right ventricle to pulmonary artery coupling (RV-PAc) describes the right ventricle’s ability to adjust to an increased afterload. In case of transthyretin amyloid cardiomyopathy (ATTR-CM), impaired RV-PAc can result from increased left ventricular diastolic stiffness due to fibril deposition.

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Main Authors: Schwarting, Stéphanie K. (Author) , Poledniczek, Michael (Author) , Metodiev, Yuliyan (Author) , Stolz, Lukas (Author) , Hofmann, Eva Catarina Maria (Author) , Hegenbart, Ute (Author) , Schönland, Stefan (Author) , Kääb, Stefan (Author) , Maßberg, Steffen (Author) , Frey, Norbert (Author) , Siepen, Fabian aus dem (Author)
Format: Article (Journal)
Language:English
Published: 20 November 2024
In: Clinical research in cardiology

ISSN:1861-0692
DOI:10.1007/s00392-024-02576-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00392-024-02576-2
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00392-024-02576-2
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Author Notes:Stéphanie K. Schwarting, Michael Poledniczek, Yuliyan Metodiev, Lukas Stolz, Eva Hofmann, Ute Hegenbart, Stefan Schönland, Stefan Kääb, Steffen Massberg, Norbert Frey, Fabian aus dem Siepen
Description
Summary:The right ventricle to pulmonary artery coupling (RV-PAc) describes the right ventricle’s ability to adjust to an increased afterload. In case of transthyretin amyloid cardiomyopathy (ATTR-CM), impaired RV-PAc can result from increased left ventricular diastolic stiffness due to fibril deposition.
Item Description:Gesehen am 16.05.2025
Physical Description:Online Resource
ISSN:1861-0692
DOI:10.1007/s00392-024-02576-2