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Does transanal total mesorectal excision (taTME) result in better quality of life and functional outcomes than traditional TME does?: a retrospective propensity score-adjusted cohort study : research

Purpose The improved prognosis of rectal cancer through modern therapeutic approaches raises questions regarding quality of life (QoL) and functional outcomes. In this study, we compared post-transanal total mesorectal excision (taTME) short- and long-term QoL and functional outcomes with those afte...

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Main Authors: Ammann, Yanic Rolf (Author) , Klein, Marie (Author) , Marti, Lukas (Author) , Warschkow, René (Author) , Ströse, Lennard (Author) , Sparn, Moritz (Author) , Jäger, Tarkan (Author) , Bischofberger, Stephan (Author) , Brunner, Walter (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2025
In: Langenbeck's archives of surgery
Year: 2025, Volume: 410, Pages: 1-12
ISSN:1435-2451
DOI:10.1007/s00423-025-03724-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00423-025-03724-6
Verlag, kostenfrei, Volltext: http://link.springer.com/article/10.1007/s00423-025-03724-6
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Author Notes:Yanic Ammann, Marie Klein, Lukas Marti, Rene Warschkow, Lennard Ströse, Moritz Sparn, Tarkan Jäger, Stephan Bischofberger, Walter Brunner
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Summary:Purpose The improved prognosis of rectal cancer through modern therapeutic approaches raises questions regarding quality of life (QoL) and functional outcomes. In this study, we compared post-transanal total mesorectal excision (taTME) short- and long-term QoL and functional outcomes with those after abdominal TME (abTME). Methods Prospective data from patients who underwent elective taTME or abTME for stage I-III rectal cancer followed by anastomosis were retrospectively propensity score-adjusted. The primary endpoint, QoL, was assessed with the European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30). Functional outcomes were the secondary endpoints. Results Among 494 patients during 2013-2022, 187 patients who underwent taTME and 62 patients who underwent abTME were included. QoL was worse after taTME at isolated time points: overall QoL (after 3 years: 72 vs. 82 points, p = 0.017) and QLQ-total (after 3 years: 81 vs. 87 points, p = 0.028; after 4 years: 82 vs. 89 points, p = 0.012). After propensity score matching, the between-group differences were still significant but smaller: overall QoL − 6 points, p = 0.021; QLQ-total − 5 points, p = 0.026. Conclusion The differences reported at isolated time points have questionable clinical relevance. Therefore, taTME and traditional abTME seem to have comparable long-term QoL and functional outcomes. Clinical trial registration ClinicalTrials.gov, NCT06505863, https://clinicaltrials.gov/search?id=NCT06505863 .
Item Description:Online veröffentlicht: 30. April 2025
Gesehen am 27.05.2025
Physical Description:Online Resource
ISSN:1435-2451
DOI:10.1007/s00423-025-03724-6

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