Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways
Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall, remains a dominant cause of death and disability globally. Quercetin has been evidenced to be effective against AS, but the exact mechanisms are still largely unclear.
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 May 2025
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| In: |
European journal of medical research
Year: 2025, Volume: 30, Issue: 1, Pages: 1-20 |
| ISSN: | 2047-783X |
| DOI: | 10.1186/s40001-025-02562-y |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40001-025-02562-y Verlag, kostenfrei, Volltext: https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02562-y 
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| Author Notes: | Xiao Liang, Jingyuan Zhang, Jiangbo Yu, Jiyi Zhao, and Shusen Yang |
| Summary: | Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall, remains a dominant cause of death and disability globally. Quercetin has been evidenced to be effective against AS, but the exact mechanisms are still largely unclear. |
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| Item Description: | Gesehen am 02.06.2025 |
| Physical Description: | Online Resource |
| ISSN: | 2047-783X |
| DOI: | 10.1186/s40001-025-02562-y |