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Selective internal radiation with Y-90 resin microspheres (SIRT) for liver metastases of gastro-intestinal stromal tumors (GIST) resistant to tyrosine kinase inhibitor (TKI) therapy

Hepatic metastases of GIST might be the dominant site of progression and resistant to available tyrosine kinase inhibitors (TKIs). Selective internal radiation therapy (SIRT) offers treatment by intratumoral radiation up to 200 Gy. We analyzed the hepatic progression-free survival (H-PFS) in a conse...

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Main Authors: Hohenberger, Peter (Author) , Rathmann, Nils-Andreas (Author) , Büsing, Karen-Anett (Author) , Menge, Franka (Author) , Jakob, Jens (Author) , Pink, Daniel (Author) , Wardelmann, Eva (Author) , Schönberg, Stefan (Author) , Diehl, Steffen J. (Author)
Format: Article (Journal)
Language:English
Published: 03 May 2025
In: British journal of cancer
Year: 2025, Volume: 132, Issue: 8, Pages: 716-724
ISSN:1532-1827
DOI:10.1038/s41416-025-02952-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41416-025-02952-3
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41416-025-02952-3
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Author Notes:Peter Hohenberger, Nils Rathmann, Karen Büsing, Franka Menge, Jens Jakob, Daniel Pink, Eva Wardelmann, Stefan O. Schoenberg and Steffen J. Diehl
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Summary:Hepatic metastases of GIST might be the dominant site of progression and resistant to available tyrosine kinase inhibitors (TKIs). Selective internal radiation therapy (SIRT) offers treatment by intratumoral radiation up to 200 Gy. We analyzed the hepatic progression-free survival (H-PFS) in a consecutive patient cohort.
Item Description:Online veröffentlicht: 5. März 2025
Gesehen am 04.06.2025
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/s41416-025-02952-3

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