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Excess glutamate in the cerebrospinal fluid in bacterial meningitis

We investigated possible neurotoxic components in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. On murine cerebellar neuronal cell cultures, CSF exerted a dose-dependent toxic effect, which was attenuated by the NMDA receptor antagonist MK-801. Glutamate concentrations in the...

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Bibliographische Detailangaben
Hauptverfasser: Spranger, Matthias (VerfasserIn) , Krempien, Sebastian (VerfasserIn) , Schwab, Stefan (VerfasserIn) , Maiwald, Matthias (VerfasserIn) , Bruno, Kathleen (VerfasserIn) , Hacke, Werner (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 1996
In: Journal of the neurological sciences
Year: 1996, Jahrgang: 143, Heft: 1, Pages: 126-131
ISSN:1878-5883
DOI:10.1016/S0022-510X(96)00197-9
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0022-510X(96)00197-9
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022510X96001979
Volltext
Verfasserangaben:Matthias Spranger, Sebastian Krempien, Stefan Schwab, Matthias Maiwald, Kathleen Bruno, Werner Hacke
Beschreibung
Zusammenfassung:We investigated possible neurotoxic components in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. On murine cerebellar neuronal cell cultures, CSF exerted a dose-dependent toxic effect, which was attenuated by the NMDA receptor antagonist MK-801. Glutamate concentrations in the CSF of patients with bacterial meningitis were measured by an enzymatic assay and found to be significantly elevated (p < 0.001) as compared to viral meningitis and non-inflammatory neurological diseases. The concentration of glutamate in the CSF of patients with bacterial meningitis varied considerably and correlated with the severity of the disease as scored by the Glasgow Coma Scale. Cells in the CSF, mainly comprising polymorphonuclear granulocytes, did not release any glutamate into the culture medium, whereas blood monocytes produced remarkable amounts. These findings implicate an important role of monocytic inflammatory cells in bacterial meningitis by the release of glutamate, which may contribute to neuronal cell death.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 15. März 2000
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Beschreibung:Online Resource
ISSN:1878-5883
DOI:10.1016/S0022-510X(96)00197-9

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